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Herpes zoster after recombinant herpes zoster vaccination - Immediate post-RHZ-vaccination evolution of CMI, HMI and lymphocyte count and typing.
EU CTIS ID: 2025-521547-20-00
What this study is testing
To investigate the sequential VZV-specific CMI and HMI as well as the lymphocyte typing before and after recombinant HZ vaccination, to better understand the post-vaccination transient specific VZV immunosuppression.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Male and female adults between 50 and 65 years of age
- Be healthy
- Willingness to sign the consent form
- Willingness to the 9 blood samples
- Willingness to receive the 2 doses of the RHZ vaccine (at 2-6 months interval)
You likely can't join if
- Intake of any immunosuppressive therapies
- Contraindication for the RHZ vaccine or one or more of the constituents
- Pre-menoposal women
- Any form of immunosuppression
- Recent live or non-live vaccination(s) (3 months prior to inclusion)
- Unwillingness to sign the consent form
See the full eligibility criteria
- Male and female adults between 50 and 65 years of age
- Be healthy
- Willingness to sign the consent form
- Willingness to the 9 blood samples
- Willingness to receive the 2 doses of the RHZ vaccine (at 2-6 months interval)
- Intake of any immunosuppressive therapies
- Contraindication for the RHZ vaccine or one or more of the constituents
- Pre-menoposal women
- Any form of immunosuppression
- Recent live or non-live vaccination(s) (3 months prior to inclusion)
- Unwillingness to sign the consent form
- Prior varicella zoster virus vaccination
- Prior herpes zoster virus vaccination
- History of prior episode of herpes zoster
- Active herpes zoster at day 0 of the study
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.