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Pilot randomized controlled trial of the prevention of early respiratory tract infections in intubated patients. Comparison of the safety and efficacy of a short course of systemic antibiotic, a cough simulator and aspiration of subglottic secretions
EU CTIS ID: 2025-521454-42-00
What this study is testing
Study the incidence of device, antibiotic and infection-associated severe adverse events, days 1 to 14. Prevention of respiratory tract infections in intubated critically ill patients from inclusion to day 14.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Endotracheal Intubation anticipated to last >48 hours
- Age >17
- Severe trauma or severe head trauma or Ischemic or hemorrhagic stroke or Status after cardiac arrest (ROSC) or Intoxications of the CNS or status epilepticus
You likely can't join if
- Hopeless prognosis
- Indication of systemic antibiotic therapy for suspected or documented infection
- Active hemoptisis or pulmonary hemorrhage
- Unstable thoracic cage
- Undrained pneumothorax (inclusion acceptable after drainge)
- Betalactam allergy
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.