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Optimization of pain management for acute renal colic in the Emergency Department – The OPTIMIZED trial
EU CTIS ID: 2025-521316-19-00
What this study is testing
The main objective of this trial is to investigate the efficacy of an Erector Spinae Plane Block (ESPB) in managing pain for acute renal colic in the ED. This study hypothesizes that ESPB is an effective adjunct to control pain in patients with renal colic, that it increases patient satisfaction, and reduces healthcare costs by minimizing hospitalizations and interventions.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age 18 years or older
- Able and willing to provide informed consent
- Confirmed urolithiasis by ultrasound (performed by radiologic expert, stone must be seen, not only secondary characteristics such as hydronephrosis) or CT-scan during ED visit
- Persistent pain (NRS ≥ 4) after radiologic confirmation of urolithiasis and initial pain medication
You likely can't join if
- Pregnant or lactating patients
- Bilateral ureter obstruction
- Anuric patients
- Patients using class III anti-arrhythmic drugs (amiodaron, ibutilide)
- Weight <37kg
- Inability to complete online questionnaires in Dutch, send via email
See the full eligibility criteria
- Age 18 years or older
- Able and willing to provide informed consent
- Confirmed urolithiasis by ultrasound (performed by radiologic expert, stone must be seen, not only secondary characteristics such as hydronephrosis) or CT-scan during ED visit
- Persistent pain (NRS ≥ 4) after radiologic confirmation of urolithiasis and initial pain medication
- Pregnant or lactating patients
- Bilateral ureter obstruction
- Anuric patients
- Patients using class III anti-arrhythmic drugs (amiodaron, ibutilide)
- Weight <37kg
- Inability to complete online questionnaires in Dutch, send via email
- Known allergy to local anaesthetics from the amide-type such as ropivacaine or bupivacaine
- Use of vitamin K antagonist with INR ≥4.5 or clotting disorders (conform guideline other nerve blocks NVSHA) [NB the use DOAC’s or thrombocyte aggregation inhibitors is not a contra-indication]
- Patients presenting with urosepsis or fever
- Patients with a solitary kidney
- Patients with a blow-out of the renal collecting system
- Patients with a skin infection at the puncture site of the ESPB
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.