BridgeMD
TMSxDCS: Medicinal improvement of brain stimulation for depression.
EU CTIS ID: 2025-521166-95-00
What this study is testing
The primary objective of this study is to investigate the antidepressive effect of augmenting a single day of accelerated transcranial magnetic stimulation (TMS) with D-cycloserine (DCS).
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- A primary diagnosis of MDD, with a current moderate to severe depressive episode (score of >20 on the MADRS)
- Age between 18-65 years old
- A diagnosis of moderate to severe measures of treatment resistant depression (TRD) and have tried at least 2 types of antidepressant medication without sufficient result
You likely can't join if
- Any change in antidepressant treatment (medication, psychotherapy) 4 weeks prior to enrollment
- Has a cochlear implant
- Metal implants near (<10 cm away from coil) the head including: - Aneurysm clips / coils - Any medical implant containing metal near the head - Metal stents in the brain - Shrapnel or bullet fragments - Implanted vagus nerve or deep brain stimulators, Electrodes for monitoring brain activity
- Pregnancy upon inclusion or during the study period, though women with childbearing potential will be included into the study.
- Primary psychiatric diagnosis other than MDD
- A history of bipolar disorder
See the full eligibility criteria
- A primary diagnosis of MDD, with a current moderate to severe depressive episode (score of >20 on the MADRS)
- Age between 18-65 years old
- A diagnosis of moderate to severe measures of treatment resistant depression (TRD) and have tried at least 2 types of antidepressant medication without sufficient result
- Any change in antidepressant treatment (medication, psychotherapy) 4 weeks prior to enrollment
- Has a cochlear implant
- Metal implants near (<10 cm away from coil) the head including: - Aneurysm clips / coils - Any medical implant containing metal near the head - Metal stents in the brain - Shrapnel or bullet fragments - Implanted vagus nerve or deep brain stimulators, Electrodes for monitoring brain activity
- Pregnancy upon inclusion or during the study period, though women with childbearing potential will be included into the study.
- Primary psychiatric diagnosis other than MDD
- A history of bipolar disorder
- A history of psychosis
- A history of schizophrenia
- A history of renal insufficiency
- Current substance abuse disorder
- Current scheduled use of benzodiazepines (as needed use is permitted, except for the day prior to treatment)
- Current use of any of the following medications: Olanzapine, clozapine, ethionamide, isoniazid
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.