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OCEAN(a)-CCTA - Olpasiran trials of Cardiovascular Events And LipoproteiN(a) reduction -Coronary Computed Tomography Angiography trial
EU CTIS ID: 2025-521117-88-00
What this study is testing
To evaluate the effect of olpasiran compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA)
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Participants must be 35 to ≤ 80 years of age
- screening Lp(a) ≥ 200 nmol/L and a history of ASCVD. Atherosclerotic cardiovascular disease is defined as a history of either myocardial infarction (MI) (presumed type 1 event due to plaque rupture/erosion) and/or coronary revascularization by percutaneous coronary intervention (PCI)
- The screening (baseline) imaging scan must meet the CCTA imaging criteria as determined by the central imaging laboratory
You likely can't join if
- CCTA not meeting CCTA imaging criteria after two attempts during the baseline CCTA visit as assessed by the central imaging laboratory.
- History of major bleeding disorder
- Planned cardiac surgery, arterial revascularization, or planned major non-cardiac surgery during the study period.
The study team makes the final eligibility decision.
Where it's taking place
- Japan
- Canada
- China
- Australia
- United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Japan; Canada; China; Australia; United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.