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High Dose Dexamethasone to Reduce Acute Postoperative Pain Following Video-Assisted Thoracoscopic Surgery Lobectomy and Segmentectomy
EU CTIS ID: 2025-520891-25-00
What this study is testing
The aim is to conduct a randomized controlled trial with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to “High-pain-responders” in patients undergoing VATS lobectomy/segmentectomy.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age >18 years
- Able to understand written and spoken Danish language
- Pain Catastrophizing Scale ≥ 20
- Patient planned to elective Video-Assisted Thoracoscopic Surgery Lobectomy/Segmentectomy
You likely can't join if
- Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, excluding inhaled steroids.
- Individuals undergoing conversion to a surgical procedure other than VATS lobectomy/segmentectomy.
- Individuals with diabetes requiring insulin treatment.
- Pregnant or breastfeeding patients.
- Patients with known allergies to the study drug.
- Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection.
See the full eligibility criteria
- Age >18 years
- Able to understand written and spoken Danish language
- Pain Catastrophizing Scale ≥ 20
- Patient planned to elective Video-Assisted Thoracoscopic Surgery Lobectomy/Segmentectomy
- Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, excluding inhaled steroids.
- Individuals undergoing conversion to a surgical procedure other than VATS lobectomy/segmentectomy.
- Individuals with diabetes requiring insulin treatment.
- Pregnant or breastfeeding patients.
- Patients with known allergies to the study drug.
- Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection.
- Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and/or antidepressant medications
- Individuals with altered pain perception due to other conditions or injuries, such as spinal cord or brain injuries, severe polyneuropathies, or neurological disorders
- Regular users of opioid medications.
- Patients requiring reoperation within the first two postoperative days
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.