BridgeMD
PROSPECTOR 2
EU CTIS ID: 2025-520888-41-00
What this study is testing
Evaluate the efficacy of prolonged oral penicillin challenge (5 days) over single dose penicillin challenge for ascertainment of true penicillin allergy (i.e. immune mediated allergy).
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Adult patients referred to the outpatient allergy clinic or inpatient allergy service (with a non-infective diagnosis) for a penicillin allergy history (i.e. amoxicillin or penicillin unspecified)
- Adult patients with an immune-mediated penicillin allergy history: 1. Delayed phenotype (> 6 hours post dose) 2. Or unknown timing
- Tolerated first dose of an oral amoxicillin challenge
- Willing and able to give consent
- Willing and able to undergo telehealth or in clinic review post challenge
- Outpatients who are not currently receiving, or are not likely to receive, beta-lactam antibiotic therapy during the 14-day study period.
You likely can't join if
- Patient age is < 18 years
- Any other illness that, in the investigator’s judgement, will substantially increase the risk associated with subject’s participation in this study
- Stevens-Johnson Syndrome, Drug Reaction with Eosinophilia and Systemic Symptoms or Acute Generalized Exanthematous Pustulosis or Toxic Epidermal Necrolysis to penicillin’s or aminocephalosporins
- Concurrent use of antihistamines or systemic steroid therapy (> 10 mg daily)
The study team makes the final eligibility decision.
Where it's taking place
- South Africa
- Canada
- United States
- Australia
- Hong Kong
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include South Africa; Canada; United States; Australia; Hong Kong. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.