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CARDIOPROTECTIVE-NEPHROPROTECTIVE EFFECTS OF SEVOFLURANE IN COMPARISON WITH PROPOFOL IN DOUBLE VALVE SURGERY. USE OF SEVOFLURANE AS A PILLAR OF PROTECTION IN EXTRACORPOREAL CIRCULATION AND POSTOPERATIVE SEDATION
EU CTIS ID: 2025-520812-33-00
What this study is testing
To evaluate the effects of sevoflurane administration intra- (including the period of extracorporeal circulation ischemia) and postoperatively in patients undergoing double valve surgery with respect to propofol in terms of reducing myocardial damage and injury. For this, the levels of NT-ProBNP and troponin I will be measured; and its impact on myocardial preservation, through the measurement of the cardiac index intraoperatively and immediately postoperatively, as well as the use of inotropes for low cardiac output syndrome.
- Phase II and Phase III (Integrated)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age ≥ 18 years. 2. Elective surgery cardiac surgery with double valve pump. 3. Use of Nido cardioplegia, common in this type of patient
You likely can't join if
- 1. History of adverse reaction to sevoflurane or propofol. 2. Severe disease of any organ (lung, liver, kidney), diagnosed preoperatively. 3. Combined surgery (e.g. coronary or carotid surgery). 4. Patients in a situation of hemodynamic instability. 5. Heart failure or need to use inotropic or vasoactive drugs prior to the intervention. 6. Treatment with oral antidiabetics not suspended at least 48 hours before. 7. Treatment with euphylline/theophylline prior to the intervention. 8. Inability to grant informed consent. 9. Pregnancy or breastfeeding.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.