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Role of inhaled nitric oxide on right ventricular function and pulmonary vascular mechanics following cardiac surgery
EU CTIS ID: 2025-520808-10-00
What this study is testing
To study the effects of inhaled iNO on pulmonary vascular mechanics, right ventricular function, and right ventricular-vascular coupling in patients in the immediate cardiac surgery post-operative period
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Obtained informed consent
- Age > 18 years
- Under passive mechanical ventilation
- Pre-operative FEVI ≥ 30%
- Absence of hypovolemia: absence of ventricular "kissing" and / or superior vena cava collapsibility index < 20%
- Stable spontaneous heart rythm
You likely can't join if
- Cor pulmonale or presence of preoperative pulmonary vascular pathology
- Chronic pulmonary hypertension (mPAP> 35 mmHg) related to advanced COPD or chronic thromboembolic disease
- Surgery involving the tricuspid or pulmonary valves
- Intra- or post-operative use of nitroprusside or nitroglycerine
- Pre-operative dependence of inotropic drugs or vasoconstrictors
- Use of levosimendan. If dobutamine is in use, patients can be included provided the infusion can be stopped or is ≤ 1 µg/kg/min
See the full eligibility criteria
- Obtained informed consent
- Age > 18 years
- Under passive mechanical ventilation
- Pre-operative FEVI ≥ 30%
- Absence of hypovolemia: absence of ventricular "kissing" and / or superior vena cava collapsibility index < 20%
- Stable spontaneous heart rythm
- Post-operative hemodynamic stability
- Cor pulmonale or presence of preoperative pulmonary vascular pathology
- Chronic pulmonary hypertension (mPAP> 35 mmHg) related to advanced COPD or chronic thromboembolic disease
- Surgery involving the tricuspid or pulmonary valves
- Intra- or post-operative use of nitroprusside or nitroglycerine
- Pre-operative dependence of inotropic drugs or vasoconstrictors
- Use of levosimendan. If dobutamine is in use, patients can be included provided the infusion can be stopped or is ≤ 1 µg/kg/min
- Pacemaker dependency
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.