Comparison of the preventive painkiller effect of etoricoxib and celecoxib after M3M surgery: A randomized, double-masked clinical trial

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• In the planned clinical trial, all patients with any of the following hypersensitivities, conditions, or diseases, whether occurring independently or in combination with other conditions, will be excluded: hypersensitivity to sulfonamides, lactose monohydrate, sodium lauryl sulfate, povidone K 30, croscarmellose sodium, magnesium stearate, gelatin, titanium dioxide, shellac, propylene glycol, iron oxide, calcium hydrogen phosphate, microcrystalline cellulose, carnauba wax, hypromellose, or triacetin. Patients who have previously experienced asthma, acute rhinitis, nasal polyps, angioneurotic edema, urticaria, or other allergic-type reactions following the use of acetylsalicylic acid or other nonsteroidal anti-inflammatory drugs (NSAIDs), including COX-2 (cyclooxygenase-2) inhibitors, will also be excluded. Pregnancy or breastfeeding, congestive heart failure, ischemic heart disease, clinically manifested forms of peripheral arterial disease and/or cerebrovascular disease, hypertension, liver failure, impaired renal function, active peptic ulcers, gastrointestinal bleeding, and inflammatory bowel disease are exclusion criteria. Due to potential drug interactions with the selective COX-2 inhibitors under investigation, patients currently on medication or who have been on long-term medication will be excluded. Additionally, patients who have taken any type of pain relief medication within one week prior to the planned wisdom tooth extraction will also be excluded. Only non-smoking patients will participate in the trial due to slower wound healing and increased postoperative complications. Similarly, pregnancy, breastfeeding, and hypersensitivity to COX inhibitors are considered exclusion criteria. Due to potential drug interactions with the selective COX-2 inhibitors under investigation, patients currently on medication or who have been on long-term medication will be excluded. Additionally, patients who have taken any type of pain relief medication within one week prior to the planned wisdom tooth extraction will also be excluded. Only non-smoking patients will participate in the trial due to slower wound healing and increased postoperative complications. Similarly, pregnancy, breastfeeding, and hypersensitivity to COX inhibitors are considered exclusion criteria.