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What are the effects of using 10 versus 20 ml of local anesthetic for Plexus Popliteal Block on opioid consumption, pain, and patient-reported information after knee replacement surgery? - a scientific randomized trial.
EU CTIS ID: 2024-520204-26-00
What this study is testing
The aim of this study is to assess the analgesic effect of Popliteal Plexus Block (PPB) with 10 mL versus 20 mL of local anesthetic as an adjunct to Femoral Triangle Block in a multimodal analgesic regimen following primary unilateral total knee arthroplasty. We hypothesize that using 20 mL of local anesthetic for PPB instead of 10 mL will decrease 24-hour postoperative opioid consumption.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age > 18 years
- Scheduled to undergo primary total knee arthroplasty in spinal anesthesia.
- Ability to give their written informed consent after having fully understood the contents of the study.
- American Society of Anesthesiologists (ASA) physical status 1, 2, or 3.
You likely can't join if
- Patients who cannot read or speak Danish.
- Patients who cannot operate or have access to a smartphone with internet connectivity (required for patient-reported outcome assessment).
- Patients with allergies or intolerance to the medicines used in the study.
- Patients with a consistent daily intake of opioids preoperatively.
- Patients who are dependent on walking aid devices preoperatively.
- Patients suffering from alcohol and/or drug abuse – based on the investigator's assessment.
See the full eligibility criteria
- Age > 18 years
- Scheduled to undergo primary total knee arthroplasty in spinal anesthesia.
- Ability to give their written informed consent after having fully understood the contents of the study.
- American Society of Anesthesiologists (ASA) physical status 1, 2, or 3.
- Patients who cannot read or speak Danish.
- Patients who cannot operate or have access to a smartphone with internet connectivity (required for patient-reported outcome assessment).
- Patients with allergies or intolerance to the medicines used in the study.
- Patients with a consistent daily intake of opioids preoperatively.
- Patients who are dependent on walking aid devices preoperatively.
- Patients suffering from alcohol and/or drug abuse – based on the investigator's assessment.
- BMI > 40.
- Diagnosed with chronic neurodegenerative disorders.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.