Authorised Phase I and Phase II (Integrated)- Other Sickle Cell Disease

A Single Arm, Open Label, Phase 1/2 Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients with Sickle Cell Disease

EU CTIS ID: 2024-519881-32-00

What this study is testing

To assess the PK of etavopivat in patients with SCD To assess the safety and tolerability of etavopivat during the 24-week primary treatment period.

Phase I and Phase II (Integrated)- Other

A plain-language read of the study's public EU CTIS listing. The study team confirms the details.

Who can take part

You may be able to join if

1. Patient’s parent, legal guardian, or legal representative has provided documented informed consent and patients have provided age-appropriate assent
2. Age > 6 months and < 18 years of age at time of enrollment, according to the enrolling cohort:  Cohort 1: age 12 to < 18 years (adolescents)  Cohort 2: age 6 to < 12 years  Cohort 3: age 2 to < 6 years  Cohort 4: age 6 months to < 2 years
3. Patient has confirmed diagnosis of SCD  Documentation of SCD genotype (HbSS, HbSβ0-thalassemia or other sickle cell syndrome variants) based on prior history of laboratory testing. Molecular genotyping is not required. SCD genotype may be determined from the results of Hb electrophoresis, high-performance liquid chromatography (HPLC), or similar testing. Note that Hb electrophoresis or HPLC is performed by the local laboratory at Screening.
4. Hemoglobin ≥ 5.5 and < 10.5 g/dL
5. Pediatric patients with severe SCD, as defined by at least 1 of the following:  2-15 episodes of documented VOC (defined in Section 8.4.2) within the 12 months prior to screening. Documentation must exist in the patient’s medical record prior to screening. Events based solely on patient recall without supporting documentation should not be counted towards eligibility.  Hospitalization for any SCD-related complication in the last 12 months prior to starting study treatment  Proteinuria, defined as an albumin:creatinine ratio (ACR) > 100 mg/g on 2 measures (separated by ≥ 1 month) as an indicator of early renal disease  History of a conditional TCD in the last 12 months prior to starting study treatment, but not currently being treated with chronic transfusion therapy (applicable to participants > 2 years of age). Conditional TCD is defined as a TAMMV of 170-199 cm/s by TCD or 155-184 cm/s by imaging TCD (TCDi).
6. For participants taking HU, the dose of HU (mg/kg) must be stable (no more than a 20% change in dosing) for at least 90 days prior to start of study treatment with no anticipated need for dose adjustments during the study, in the opinion of the investigator

You likely can't join if

1. Female who is breastfeeding or pregnant
10. Receipt of prior cellular based therapy (e.g., hematopoietic cell transplant, gene modification therapy)
2. More than 15 VOCs (as defined in Section 8.4.2) within the 12 months prior to starting study treatment that required a hospital, emergency room (ER), or clinic visit
3. Hospitalized for sickle cell crisis or other vaso-occlusive event occurring in the 14 days prior to starting study treatment
4. Abnormal TCD in the 12 months prior to starting study treatment
5. Patients receiving regularly scheduled blood (RBC) transfusion therapy (also termed chronic, prophylactic, or preventive transfusion)

See the full eligibility criteria

Who can join

1. Patient’s parent, legal guardian, or legal representative has provided documented informed consent and patients have provided age-appropriate assent
2. Age > 6 months and < 18 years of age at time of enrollment, according to the enrolling cohort:  Cohort 1: age 12 to < 18 years (adolescents)  Cohort 2: age 6 to < 12 years  Cohort 3: age 2 to < 6 years  Cohort 4: age 6 months to < 2 years
3. Patient has confirmed diagnosis of SCD  Documentation of SCD genotype (HbSS, HbSβ0-thalassemia or other sickle cell syndrome variants) based on prior history of laboratory testing. Molecular genotyping is not required. SCD genotype may be determined from the results of Hb electrophoresis, high-performance liquid chromatography (HPLC), or similar testing. Note that Hb electrophoresis or HPLC is performed by the local laboratory at Screening.
4. Hemoglobin ≥ 5.5 and < 10.5 g/dL
5. Pediatric patients with severe SCD, as defined by at least 1 of the following:  2-15 episodes of documented VOC (defined in Section 8.4.2) within the 12 months prior to screening. Documentation must exist in the patient’s medical record prior to screening. Events based solely on patient recall without supporting documentation should not be counted towards eligibility.  Hospitalization for any SCD-related complication in the last 12 months prior to starting study treatment  Proteinuria, defined as an albumin:creatinine ratio (ACR) > 100 mg/g on 2 measures (separated by ≥ 1 month) as an indicator of early renal disease  History of a conditional TCD in the last 12 months prior to starting study treatment, but not currently being treated with chronic transfusion therapy (applicable to participants > 2 years of age). Conditional TCD is defined as a TAMMV of 170-199 cm/s by TCD or 155-184 cm/s by imaging TCD (TCDi).
6. For participants taking HU, the dose of HU (mg/kg) must be stable (no more than a 20% change in dosing) for at least 90 days prior to start of study treatment with no anticipated need for dose adjustments during the study, in the opinion of the investigator
7. Patients on crizanlizumab or L-glutamine treatment at the time of consent may be eligible if they:  Have been on a stable dose for ≥ 12 months at the time of consent (ie, no changes to the dose except for changes to weight or for safety reasons)  For patients on crizanlizumab, have been ≥ 80% compliant with the planned regimen during the 12 months prior to the time of consent
8. Female patients of childbearing potential who are using acceptable methods of contraception and agree not to donate ova from study start to 90 days after the last dose of study drug, and male patients who are willing to use acceptable methods of contraception and agree not to donate sperm, from study start to 90 days after the last dose of study drug.

What rules you out

1. Female who is breastfeeding or pregnant
10. Receipt of prior cellular based therapy (e.g., hematopoietic cell transplant, gene modification therapy)
2. More than 15 VOCs (as defined in Section 8.4.2) within the 12 months prior to starting study treatment that required a hospital, emergency room (ER), or clinic visit
3. Hospitalized for sickle cell crisis or other vaso-occlusive event occurring in the 14 days prior to starting study treatment
4. Abnormal TCD in the 12 months prior to starting study treatment
5. Patients receiving regularly scheduled blood (RBC) transfusion therapy (also termed chronic, prophylactic, or preventive transfusion)
6. Received any blood products within 30 days of starting study treatment
7. Receiving or use of concomitant medications that are strong inducers of cytochrome P450 (CYP) 3A4 within 2 weeks of starting study treatment
8. Use of voxelotor within 28 days prior to starting study treatment or anticipated need for this agent during the study
9. Receipt of erythropoietin or other hematopoietic growth factor treatment within 28 days of starting study treatment or anticipated need for such agents during the study

The study team makes the final eligibility decision.

Where it's taking place

United States
Lebanon
Nigeria
Kenya
United Kingdom

Questions & answers

Do participants get paid in this trial?

This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.

Is it free to join, and do I need insurance?

Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.

How long does this study last?

The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.

Who can join this trial?

This study is enrolling all sexes, 0-17 years. The study team makes the final eligibility decision.

Where is this trial taking place?

Study sites include United States; Lebanon; Nigeria; Kenya; United Kingdom. Enter your location above to see the nearest site and check your eligibility.

Explore other conditions

Obesity Type 2 diabetes Type 1 diabetes Prediabetes Weight loss Metabolic syndrome High cholesterol High triglycerides High blood pressure PCOS Hypothyroidism Thyroid disease Gout Fatty liver disease (NAFLD/NASH)Heart failure Coronary artery disease

BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.