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Treatment of bowel dysfunction after surgery for rectal cancer using transanal irrigation or laxatives
EU CTIS ID: 2024-519492-25-01
What this study is testing
To investigate if patients who experience unsatisfactory improvement of bowel function and QOL by the end of the RCT when treated with glycerol suppositories, will improve on these parameters when treated with TAI and vice versa.
- Phase III and phase IV (Integrated)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- 1. Patients electively treated for rectal cancer with a low anterior resection. 2. Unsuccessful PCT after at least 4 weeks of treatment for LARS (LARS score >29 at evaluation). 3. At least 3 months after surgery (including reversal of a temporary loop-ileostomy). 4. Age 18 years 5. Ability to understand written and spoken language actual for the including site (due to questionnaire validity).
You likely can't join if
- 1. Former use of TAI 2. Prior systematic use of rectal emptying aids 3. Anastomotic stenosis 4. History of anastomotic leakage 5. Current metastatic disease or local recurrence 6. Ongoing oncological treatment 7. Postoperative radiotherapy for rectal cancer 8. Previous or current cancer in other pelvic organs than the rectum 9. Underlying diarrhoeal disease 10. Inflammatory bowel disease 11. Dementia 12. Spinal cord injury, multiple sclerosis, Parkinson’s disease or other significant neurologic disease assessed to be a contributory cause to LARS symptoms. 13. Inability of patient to use TAI 14. Inability and unwillingness to give informed consent 15. Pregnancy or intention to become pregnant during the trial period
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.