Influence Of Zoledronic Acid On Healing After Arthroskopic Repair Of Chronic Rotator Cuff Lesions A Prospective, Randomized, Placebo-Controlled Phase II Trial ZORRO

You likely can't join if

•  Patients younger than 50 or older than 70 years of age  Pregnancy  Known allergy to zoledronic acid or other components of the medicinal product  Previous fracture of the affected shoulder  Previous surgery of the affected shoulder  Previous or existing bacterial infection of the affected shoulder  Rupture of more than two tendons in the affected shoulder (massive rotator cuff tear)  Isolated subscapularis tendon tear  Presence of glenohumeral osteoarthritis (Hamada type 3 or higher)  Diabetes mellitus (fasting glucose ≥ 126 mg/dl, HbA1C ≥ 6.5%)  Malignant tumor disease  Pathological dental status  Known disease that interferes with bone metabolism  Concomitant diseases that do not permit general anesthesia  Previous therapy with anti-osteoporotic drugs (bisphosphonates, denosumab, teriparatide)  Epilepsy  Claustrophobia  Chronic alcohol abuse  Drug abuse