BridgeMD
The FIND study
EU CTIS ID: 2024-518908-46-00
What this study is testing
The main objective is to compare the proportion of patients with ACTH-dependent hypercortisolism in whom Cushing's disease (CD) is correctly differentiated from ectopic Cushing's syndrome (CS) using [18F]FET PET-MRI compared to IPSS.
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Age ≥18 years 2. Biochemically confirmed ACTH-dependent hypercortisolism, defined as: Non-suppressed ACTH levels plus minimal 2 of the following: Overnight 1mg dexamethasone suppression test > 50 nmol/L; and/or Elevated late night salivary cortisol (min. 2/3 measurements); and/or Elevated 24-hours urinary free cortisol (min. 2 measurements) 3. Pituitary microadenoma (< 10mm) OR negative / inconclusive findings on standard MRI of the pituitary sella-region. 4. Indication for further evaluation with IPSS.
You likely can't join if
- A potential subject who meets any of the following criteria will be excluded from participation in this study: 1. Non-ACTH dependent hypercortisolism; 2. Pituitary macroadenoma (≥ 10mm); 3. Suspicion of Pseudo-Cushing’s disease (e.g. due to alcohol use disorder, PCO’s, obesity, depression) according to standard work up / guidelines; 4. Use of glucocorticosteroids; 5. Impaired renal function, defined as eGFR (MDRD) <30ml/min/1,73 m2. An exception can be made in consultation with the treating physician; 6. Impaired Liver function; 7. Pregnancy/breastfeeding. For the latter, temporary discontinuation may be considered; 8. Known allergic reaction to therapeutic radiopharmaceuticals; 9. Inability to lie still in supine position for the duration of the PET-MRI scan; 10. • Other conditions that make it impossible to perform a PET-MRI scan, such as neurological disease, severe immobility, or unsuppressable claustrophobia.
The study team makes the final eligibility decision.
Where it's taking place
- Switzerland
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Switzerland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.