RA-P-OCD-01

You may be able to join if

• Patients to be included in this study meet the criteria for at least one of the following ICD 10 CM diagnoses: o Obsessive-compulsive disorder ICD F42 or o Obsessive-compulsive behavior ICD R46.81 o Schizophrenia, delusional, and other non-mood psychotic disorders, namely  F20 Schizophrenia  F22 Delusional disorders  F23 Brief psychotic disorder  F25 Schizoaffective disorders  F28 Other psychotic disorder not due to a substance or known physiological condition  F29 Unspecified psychosis not due to a substance or known physiological condition
• The clinical picture indicates active inflammatory activity (see specific criteria below), potential for rehabilitation and time from disease and/or episode debut is no longer than 10 years.
• Acute (<12 weeks) or atypical debut, or episodes of any of the following: a. Symptoms of encephalopathy:  psychotic symptoms, including hallucinations, delusions, paranoia, disorganized speech, disorganized behavior  agitation, confusion  sudden change in personality as perceived by the social environment  drowsiness  loss of functions in daily life  cognitive problems (memory, speech, learning)  emotional dysregulation b. Focal neurological symptoms, e.g.  ataxia, dystonia, myoclonus, sensory losses, paresthesia c. Psychomotor anomaly,  e.g. retardation, catatonic symptoms, parkinsonism d. Loss of drive (sleep, appetite, libido, motivation) e. Obsessions, compulsions (OCD/OCB), f. Hypo- or hypervigilance (for e.g sounds, emotions, other peoples´ or own behavior) g. Sleeping disorders, AND
• AND At least one of the following criteria: a. Prodromal phase with infection or symptoms of infection (fever, malaise, etc) b. Clinical improvement of psychiatric symptoms after treatment with anti-inflammatory medications other than antibody therapy (such as steroids, NSAIDs IVIG, plasmaphereses), or antibiotics c. Radiological evidence of neuroinflammation (MR) d. EEG pathology or witnessed epileptic seizure e. Biochemical evidence of inflammation, autoimmunity or blood-brain barrier dysfunction in blood or CSF samples, such as one of the following:  presence of oligoclonal bands  elevated CSF cell count  elevated albumin quotient, or elevated albumin in CSF  elevated IgG ratio  elevated levels of neurofilament f. Patient history of autoimmune disorder not associated with neuroinflammation, such as type 1 diabetes, rheumatoid arthritis, Sjögren´s syndrome, inflammatory bowel disease (IBD, comprising Crohn´s disease and ulcerative colitis), celiac disease, Grave´s disease, Hashimoto`s thyroiditis g. Biochemical indication of autoimmunity such as elevated serum anti-TPO, ANA, ANCA, RF or GAD antibodies, PANDAS panel with relationship to symptom development.
• Age: 18-55
• Severity: Clinical Global impression (CGI): Minimum score of “4 = Moderately ill”