Reducing Non-Alcoholic Steatohepatitis

You likely can't join if

• • Contraindication of liver biopsy • A documented episode of ketoacidosis • Contraindication or hypersensitivity to empagliflozin • A presence of an acute or chronic disease that could endanger the safety or health of the patient by discretion of the examiner • Value of HbA1c > 80 mmol/mol. • The inability to exclude thiazolidinedione (pioglitazone) from chronic medication. • Liver affection of different etiology, including hepatitis B a C , autoimmune hepatitis, alpha-1 antitrypsin insufficiency, hemochromatosis, Wilson disease, primary sclerosing cholangitis, primary biliary cirrhosis or liver cirrhosis (Child-Pugh A, B, C) of any etiology • The use of drugs or medicine inducing steatosis or liver fibrosis. • Verified use of ethanol: men >30 g/day, woman > 20 g/day • History of acute o chronic pancreatitis. • Known abuse of and or an addiction to illegal substances • A verified fluctuation of body weight +/- 10 % in the last 3 months. • A diagnosis of a malignant disease (with the exclusion of threated dermal malignancies) in the last 5 years. • Cerebral stroke or cardiac infarction in the last 6 months. • Clinically significant shortness of breath defined as NYHA III or more. • Verified heart failure with associated decrease of ejection fraction of the left ventricle less than 40 %. • Values of eGFR lower than 30 ml/min/1,73 m2 or if CrCl is lower than 30 ml/min. • Syndrome of the diabetic foot with the need for amputation or an active ulcer • Planed pregnancy, active lactation or pregnancy, positivity in a pregnancy test, absence of at least 2 adequate contraceptive methods in women of fertile age. • Participation in a different study in the last 3 months before the start of the study. • Incapacity or diminished capacity to perform legal acts. • Pending execution of a sentence.