BridgeMD
InvestiGating the rOle of Growth Hormone in hepatic lipid metabolism in humans
EU CTIS ID: 2024-518214-11-01
What this study is testing
We aim to define the role of GH action in modifying HCL by regulating hepatic VLDL secretion, DNL and energy metabolism in healthy humans.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age between 18 – 70 years
- for healthy volunteers: Plasma trigylcerides: < 300 mg/dl
- for healthy volunteers: male sex
You likely can't join if
- for healthy volunteers: HbA1c > 6%
- for healthy volunteers: metal devices or other magnetic material in or on the subjects body which will be hazardous for NMR investigation [heart pacemaker, coronary stents and heart valves (in case these devices are not compatible with a 7T MT), brain (aneurysm) clip, nerve stimulators, electrodes, ear implants, penile implants, colored contact lenses, patch to deliver medications through the skin, vascular filter for blood clots, orthodontic braces, shunt-spinal or ventricular, any metal implants (rods, joints, plates, pins, screws, nails, or clips), embolization coil, or any metal fragments or shrapnel in the body.
- for patients with acromegaly: serum TGs > 500 mg/dl
- for patients with acromegaly: severe liver disease (LFTs 3x ULN)
- for patients with acromegaly: glomerular filtration rate < 45 mL/min
- history of pancreatitis
See the full eligibility criteria
- Age between 18 – 70 years
- for healthy volunteers: Plasma trigylcerides: < 300 mg/dl
- for healthy volunteers: male sex
- for healthy volunteers: HbA1c > 6%
- for healthy volunteers: metal devices or other magnetic material in or on the subjects body which will be hazardous for NMR investigation [heart pacemaker, coronary stents and heart valves (in case these devices are not compatible with a 7T MT), brain (aneurysm) clip, nerve stimulators, electrodes, ear implants, penile implants, colored contact lenses, patch to deliver medications through the skin, vascular filter for blood clots, orthodontic braces, shunt-spinal or ventricular, any metal implants (rods, joints, plates, pins, screws, nails, or clips), embolization coil, or any metal fragments or shrapnel in the body.
- for patients with acromegaly: serum TGs > 500 mg/dl
- for patients with acromegaly: severe liver disease (LFTs 3x ULN)
- for patients with acromegaly: glomerular filtration rate < 45 mL/min
- history of pancreatitis
- for healthy volunteers: serum TGs > 300 mg/dl
- for healthy volunteers: known liver or kidney disease (AST/ALT > ULN, GFR < 65 ml/min)
- for healthy volunteers: consummation of alcoholic beverages during the last 48 hours
- for healthy volunteers: Body-Mass-Index > 30 kg/m²
- for healthy volunteers: tendency towards claustrophobia
- simultaneous participation in another active clinical study
- allergies against soy products, eggs, peanuts
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.