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Lung Microbiota’s evolution after use of Nitrous Oxide on pediatric patient needing airway samples - MicroNO
EU CTIS ID: 2024-518197-14-00
What this study is testing
To determine whether the use of MEOPA alters the composition of respiratory microbiota collected by induced sputum in children requiring respiratory sampling for suspected lower respiratory tract infection.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Children aged 3 months to 8 years
- Patients requiring ECBC sampling in routine practice: acute respiratory distress with suspected lower respiratory infection (superinfected bronchiolitis or asthma attacks, suspected pneumonitis) and severe asthma
- Free, informed and written consent from at least one of the minor's legal representatives
- Affiliated to the social security system
- Child unable to expectorate effectively
You likely can't join if
- Contraindication of MEOPA : - Patients requiring 100% oxygen ventilation - Intracranial hypertension - Altered state of consciousness preventing cooperation - Any condition where air is trapped́ inside the body and its expansion could be dangerous (cranial and/or maxillofacial trauma, pneumothorax, emphysema, gas embolism, following recent scuba diving, decompression accident, during middle ear/internal ear or sinus surgery, abdominal gas distension, if air is injected into the epidural space during epidural anesthesia, if the patient has received ophthalmic gas for as long as the gas bubble persists and up to 3 months afterwards) - Known, unsubstituted vitamin B12 or folic acid deficiency - Recent onset of unexplained neurological abnormalities.
- Contraindications for induced expectoration: Clinical instability not conducive to induced expectoration (at practitioner's discretion) - Severe respiratory insufficiency, - Severe spasticity. - Hemoptysis - Decompensated heart failure - Contraindications to the use of hypertonic saline : o Hypersensitivity of the bronchial system to hypertonic sodium chloride solutions. o Hemoptysis. - Contraindication to the use of salbutamol o Hypersensitivity to any of the constituents of salbutamol-based pressurized or inhaled products. - Intolerance to salbutamol-based pressurized or inhaled products (coughing or bronchospasm occurring immediately after inhalation of the product). Contraindication to maneuvers performed by physiotherapists: bullous emphysema, confirmed hiatal or diaphragmatic hernia and rib fragility.
- Patient with minor parent(s)
- Antibiotic therapy administered within the previous 24 hours.
- Uncooperative child
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 0-17 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.