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Intraoperative methadone in orthopedic surgery
EU CTIS ID: 2024-518059-50-00
What this study is testing
Determine the effects of methadone on analgesic requirements and pain scales in the first 24 hours after orthopedic surgery without locoregional anesthesia, compared to patients receiving standard doses of sufentanil.
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age between 18 and 80 years old
- ASA 1-3 status
- Elective partial or total hip and knee arthroplasty
You likely can't join if
- Preoperative renal failure (serum creatinine > 2 mg/dL or 1.5-fold increase in basal plasma creatinine or GFR < 50 ml/min/1.73m2)
- Significant hepatic dysfunction (PT <50% or increase in 3 times basal transaminases)
- Known heart failure
- Preoperative hemodynamic instability (preoperative use of inotropes or vasopressors)
- Known methadone or sufentanil allergy
- Preoperative opioid use or history of opioid abuse
See the full eligibility criteria
- Age between 18 and 80 years old
- ASA 1-3 status
- Elective partial or total hip and knee arthroplasty
- Preoperative renal failure (serum creatinine > 2 mg/dL or 1.5-fold increase in basal plasma creatinine or GFR < 50 ml/min/1.73m2)
- Significant hepatic dysfunction (PT <50% or increase in 3 times basal transaminases)
- Known heart failure
- Preoperative hemodynamic instability (preoperative use of inotropes or vasopressors)
- Known methadone or sufentanil allergy
- Preoperative opioid use or history of opioid abuse
- Pregnancy and breastfeeding
- Treatment with beta blockers and HR < 60 bpm
- Treatment with antidepressants
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.