A Pilot, Randomized, Double-Blinded, Controlled Study of Hemodynamic and Acid Base Effects of 0.5M Sodium Lactate and 3% Saline Solutions in Septic Shock Patients

You may be able to join if

• Subjects will be eligible for the trial if they meet all of the following criteria: 1. Age criteria: 18 – 90 years 2. Septic shock - Sepsis 3 criteria : a) acute change in total SOFA score ≥ 2 due to infection b) use of vasopressor drug to maintain target mean arterial pressure ≥ 65 mmHg c) blood lactate level ≥ 2 mmol/L within last 24 hours 3. Likely need for fluid resuscitation a) poor peripheral perfusion as evidenced by 2 out of 4: i. peripheral cyanosis with delayed capillary refill ≥ 3 seconds ii. low urinary output (< 0.5 ml/kg/hour for at least 6 hours) iii. central venous O2 saturation < 70% iv. clouded sensorium/poor mentation b) dynamic assessment of preload responsiveness as evidenced by 1 out of 3: i. positive passive leg raising test ii. pulse pressure variation and / or stroke volume variation2, both > 12% iii. distensibility index of inferior vena caval diameter > 12% 4. Signed the relevant informed consent form (more in Chapter 10.1)