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Lu177-Dotatate every 16 weeks to reduce adverse events in patients with midgut neuroendocrine tumors
EU CTIS ID: 2024-517921-14-00
What this study is testing
To demonstrate decreased serious hematological toxicity with a less intensive RLT regimen in slowly progressive advanced Grade 1-2 midgut NETs.
- Phase I and Phase II (Integrated)- Other
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients who have histologically confirmed diagnosis of unresectable, advanced or metastatic midgut NETs (originated in the jejunum-ileum or right colon) who are candidates to receive 177Lu-Dotatate targeted radioligand therapy (RLT) and SSA. Patients with a large SRI+ mesenteric mass with abdominal-dominant disease judged by the investigator to be a midgut NET will also be eligible.
- Patients ≥ 18 years of age.
- Recovery to Grade ≤ 1 from any adverse event (AE) from prior treatment (excluding alopecia and/or asthenia).
- Life expectancy ≥ 12 months.
- Patients with health coverage (public or private), that includes coverage for patients enrolled in clinical trials, to both study treatments and determinations/procedures.
- Female subject must provide a negative urine pregnancy test at screening, and must agree to use a medically accepted and highly effective birth control method (i.e. those with a failure rate less than 1%) for the duration of the study treatment and for 7 months after the final dose of study treatment. Sexually active men must agree to use the male condom during the study and until at least 7 months after the final administration of study treatment. Additionally, it is recommended that your female partner of childbearing age use a highly effective method of contraception.
You likely can't join if
- Patients who have known hypersensitivity to lutetium-177 (177Lu), oxodotreotide, DOTA, somatostatin analogues, lysine, arginine, or any excipient/derivative of these agents.
- Male patients must agree not to donate sperm starting at screening and throughout the study period, and for at least 4 months after the final study drug administration.
- Pregnancy or lactation. Men and women should not procreate during study treatment and until seven months after the final study drug administration.
- For female patients of childbearing potential (defined as < 2 years after last menstruation and not surgically sterile) and male patients who are not surgically sterile and have female partners of childbearing potential that do not agree to use a medically accepted and highly effective birth control method (i.e. those with a failure rate less than 1%) for the duration of the study treatment and for 7 months after the final dose of study treatment.
- Patient under guardianship or curatorship or deprived of liberty by a judicial or administrative decision or patient unable to give consent.
- Prior external beam radiation therapy (EBRT) to more than 25% of the bone marrow.
See the full eligibility criteria
Who can join
- Patients who have histologically confirmed diagnosis of unresectable, advanced or metastatic midgut NETs (originated in the jejunum-ileum or right colon) who are candidates to receive 177Lu-Dotatate targeted radioligand therapy (RLT) and SSA. Patients with a large SRI+ mesenteric mass with abdominal-dominant disease judged by the investigator to be a midgut NET will also be eligible.
- Patients ≥ 18 years of age.
- Recovery to Grade ≤ 1 from any adverse event (AE) from prior treatment (excluding alopecia and/or asthenia).
- Life expectancy ≥ 12 months.
- Patients with health coverage (public or private), that includes coverage for patients enrolled in clinical trials, to both study treatments and determinations/procedures.
- Female subject must provide a negative urine pregnancy test at screening, and must agree to use a medically accepted and highly effective birth control method (i.e. those with a failure rate less than 1%) for the duration of the study treatment and for 7 months after the final dose of study treatment. Sexually active men must agree to use the male condom during the study and until at least 7 months after the final administration of study treatment. Additionally, it is recommended that your female partner of childbearing age use a highly effective method of contraception.
- Subject agrees not to participate in another interventional study while on treatment in the present study.
- Ki-67 index ≤20%
- Disease progression per RECIST v1.1 within 36 months prior to study entry.
- Patients may be treatment naïve (first-line) or have received prior systemic therapy except for any type of prior RLT (not restricted to 177Lu-Dotatate).
- In somatostatin receptor (SSTR) imaging all RECIST v1.1 evaluable target lesions and non-target lesions need to be SSTR positive (SSTR+) as defined by equal or above the liver uptake (this includes lesions of at least 10 mm in diameter in CT or MRI). If an FDG PET is performed (not mandatory), all FDG PET positive RECIST v1.1 lesions should also be somatostatin receptor positive in SSTR imaging
- Measurable disease according to RECIST v1.1 criteria
- Adequate organ function (hematological, renal and liver) based upon meeting all of the following laboratory criteria: Neutrophil count (ANC) ≥ 2,000/mm3. Platelet count ≥ 75 × 109/L. Hemoglobin ≥ 8 g/dL. Serum bilirubin ≤ 3.0 × upper limit of normal (ULN) or ≤ 3 × ULN for subjects with Gilbert’s disease. Serum albumin <3.0 g/dL unless prothrombin time is within the normal range. Creatinine clearance (CrCl) ≥ 50 mL/min as estimated by the Cockroft-Gault formula or as measured by 24-hour urine collection (GFR can also be used instead of CrCl). Note: renal tract obstruction is not allowed. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN or ≤ 5 xULN for subjects with liver metastases.
- Karnofsky performance status (KPS) scale ≥ 70%.
- Patient information and signing of the consent form, Institutional Review Board (IRB)/Independent Ethics Committee (IEC) approved, before any study-specific procedure. The patient must be able and willing to cooperate in monitoring study visits and procedures.
What rules you out
- Patients who have known hypersensitivity to lutetium-177 (177Lu), oxodotreotide, DOTA, somatostatin analogues, lysine, arginine, or any excipient/derivative of these agents.
- Male patients must agree not to donate sperm starting at screening and throughout the study period, and for at least 4 months after the final study drug administration.
- Pregnancy or lactation. Men and women should not procreate during study treatment and until seven months after the final study drug administration.
- For female patients of childbearing potential (defined as < 2 years after last menstruation and not surgically sterile) and male patients who are not surgically sterile and have female partners of childbearing potential that do not agree to use a medically accepted and highly effective birth control method (i.e. those with a failure rate less than 1%) for the duration of the study treatment and for 7 months after the final dose of study treatment.
- Patient under guardianship or curatorship or deprived of liberty by a judicial or administrative decision or patient unable to give consent.
- Prior external beam radiation therapy (EBRT) to more than 25% of the bone marrow.
- Prior whole liver internal radiation therapy (SIRT)
- Prior radioligand therapy (RLT) (not restricted to 177Lu-Dotatate).
- Prior major surgery, systemic therapy, embolization or other locoregional treatments within 4 weeks of study entry.
- Patients who have a known active Hepatitis B (e.g., HBsAg reactive) or active hepatitis C (e.g., HCV RNA [qualitative] is detected). Patients who have a known active human immunodeficiency virus (HIV) infection (HIV 1 or 2).
- Other known malignancies unless cured or definitively treated with no evidence of recurrence for 3 years.
- Serious non-malignant disease (e.g. psychiatric, infectious, autoimmune, cardiovascular or dementia), that may interfere with the objectives of the trial or with the safety or compliance of the patient, as judged by the investigator.
- Female patients must agree not to breastfeed or donate ovules starting at screening and throughout the study period, and for at least 7 months after the final study drug administration.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.