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The effect of epinephrine, norepinephrine and phenylephrine on intraoperative hemodynamic performance – a prospective double-blinded randomized clinical trial
EU CTIS ID: 2024-517373-25-00
What this study is testing
Time weighted average (TWA) of cardiac output between continuous infusion of epinephrine, norepinephrine and phenylephrine.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- ≥ 45 years old
- Scheduled for moderate- to high-risk major open abdominal surgery expected to last at least 2 hours
- ASA physical status ≥ 2
- At least one of the following risk factors (a-j): a. Age ≥ 75 years b. History of peripheral arterial disease c. History of coronary artery disease d. History of stroke or transient ischemic attack e. History of chronic kidney disease f. Diabetes requiring medical treatment g. Current smoking or history of 15 pack-years h. History of heart failure i. Preoperative high-sensitivity Troponin T ≥ 14ng.L-1 j. Preoperative NT-proBNP ≥ 200 pg.mL-1
You likely can't join if
- Scheduled for pheochromocytoma surgery
- Scheduled for liver and kidney transplantation
- Requiring preoperative intravenous vasopressor medications
- Contraindications to epinephrine, norepinephrine or phenylephrine per clinical judgement
- Permanent atrial fibrillation
- Preoperative heart rate >110 bpm
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.