Nitrous oxide detection - A study in healthy volunteers to help victims of nitrous oxide related crimes

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• Psychiatric and neurological: • Current or previous substance abuse, N2O abuse or alcohol abuse • A psychiatric disorder that requires medical treatment, incl. major depression • A diagnosis of epilepsy • Symptoms of peripheral neuropathy Cardiopulmonary: • Displaying symptoms of pneumothorax, pneumopericardium, bullous emphysema, gas emboli or severe cranial trauma. • Recent history of coronary artery bypass grafting (CABG) operation with extra corporeal membrane oxygenation (ECMO). • Uncontrolled asthma defined by occurrence of asthma symptoms within the last month prior to inclusion. Anesthesiological: • History of adverse reactions to anaesthesia. • Previous allergic or adverse reaction to N2O • Facial abnormalities that cause a participant to be unable to fit a nasal cannula intended for gas delivery. Occupational: • History of diving within 2 days • Inability to refrain from diving for 2 days following the experiment • Work environmental exposure to N2O • Intake of N2O within the last 3 months Interactions with medications: • Treatment with methotrexate • Treatment with benzodiazepines, opioids, or another CNS-depressant medicinal product • Treatment with physician prescribed vitamin B12 • Recent intraocular injection of gas. Gastroentestital: • Vitamin B12 deficiency • Participant with severely dilated intestines. • History of impaired hepatic or renal function Gynecological/ obstetrical: • Pregnant and breastfeeding women (Fertile women (defined as amenorrhea for less than 12 months) must have a negative HCG pregnancy test prior to intake of the trial medication)