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ATLAS trial
EU CTIS ID: 2024-517233-40-00
What this study is testing
The main objective of this trial is to establish if adding antibiotic treatment to surgical drainage of perianal abscess results in less perianal fistulas.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Adults >18 years old
- Eligible for email questionnaires
- Sufficient understanding of the Dutch written language (reading and writing)
- Obtained written informed consent
You likely can't join if
- A coexistent anorectal/anal fistula
- Kidney failure (eGFR <30 ml/min)
- Pregnancy or lactation
- Postoperative antibiotic prophylaxis indicated for another reason
- Immunosuppressive medication at the time of surgery
- Allergy to ciprofloxacin or metronidazole
See the full eligibility criteria
- Adults >18 years old
- Eligible for email questionnaires
- Sufficient understanding of the Dutch written language (reading and writing)
- Obtained written informed consent
- A coexistent anorectal/anal fistula
- Kidney failure (eGFR <30 ml/min)
- Pregnancy or lactation
- Postoperative antibiotic prophylaxis indicated for another reason
- Immunosuppressive medication at the time of surgery
- Allergy to ciprofloxacin or metronidazole
- Not able or trouble with swallowing pills
- Concomitant use of:Tizanidine, theophylline, clozapine, olanzapine, pirfenidone, carbamazepine, agomelatine (these are all CYP1A2 substrates, ciprofloxacin is an inhibitor) o Amiodarone, erythromycin, sotalol, azithromycin, citalopram, escitalopram, flecainide, fluconazole, haloperidol >5mg/day, methadone, ondansetron (concerning prolonged QT interval in combination with ciprofloxacin), Lithium (can cause toxic levels with metronidazole), Lopinavir/ritonavir, ritonavir capsules, temsirolimus, disulfiram (antabuse), mebendazole (can cause serious side effects, confusion and psychosis in combination with metronidazole), corticosteroids (in combination with ciprofloxacin higher risk of tendinitis and tendon rupture).
- Recurrent anorectal abscess
- Any additional surgical procedure performed during the same session
- Previous (peri)anal surgery
- Inflmmatory bowel disease
- History of radiation of the pelvic area
- (previous) anorectal malignancy
- Immunodeficiency
- Valvular heart disease
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.