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CardioPulmonary resuscitation with Argon (CPAr) trial
EU CTIS ID: 2024-516864-27-00
What this study is testing
The objective of the CPAr trial is to evaluate the efficacy in reducing post-CA neurological injury of Ar 70%/O2 30% ventilation in patients resuscitated from OHCA with an experimental ventilator, specifically modified to permit Ar/O2 ventilation.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- witnessed non-traumatic OHCA of presumably cardiac etiology with a presenting shockable rhythm
- age ≥ 18 years
- unconsciousness after return of spontaneous circulation (ROSC)
- duration of CPR ≤ 40 mins
- Initiation of study intervention ≤ 4 hrs from ROSC
- stable SaO2 ≥ 94% (according to the physician’s criteria), with a FiO2 of 30%
You likely can't join if
- age < 18 years
- initiation of the study intervention > 4 hrs from ROSC
- participation to another clinical trial
- non-witnessed CA
- CA of traumatic origin
- non-presumably cardiac cause
See the full eligibility criteria
- witnessed non-traumatic OHCA of presumably cardiac etiology with a presenting shockable rhythm
- age ≥ 18 years
- unconsciousness after return of spontaneous circulation (ROSC)
- duration of CPR ≤ 40 mins
- Initiation of study intervention ≤ 4 hrs from ROSC
- stable SaO2 ≥ 94% (according to the physician’s criteria), with a FiO2 of 30%
- age < 18 years
- initiation of the study intervention > 4 hrs from ROSC
- participation to another clinical trial
- non-witnessed CA
- CA of traumatic origin
- non-presumably cardiac cause
- non-shockable presenting rhythm (pulseless electrical activity and asystole)
- women of childbearing potential defined as younger of 50 years
- pregnancy
- known terminal illness
- pre-CA cerebral performance category (CPC) ≥ 3
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.