BridgeMD
HOPE study
EU CTIS ID: 2024-516642-19-01
What this study is testing
Compare the clinical benefit of standard blood pressure management after mechanical thrombectomy versus a specific protocol aimed at hemodynamic optimization, where blood pressure targets are applied based on the degree of recanalization achieved during the procedure. Compare the clinical benefit of standard blood pressure management after mechanical thrombectomy versus a specific protocol aimed at hemodynamic optimization, where blood pressure targets are applied based on the degree of recanalization achieved during the procedure.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients with acute ischemic stroke and large intracranial vessel occlusion within 24 hours of symptom onset who have undergone mechanical thrombectomy.
- Successful recanalization, defined as a TICI score of 2b, 2c, or 3.
- Prior score on the modified Rankin Scale (mRS) of 0, 1, or 2.
- The patient or their legal representative provides informed consent in writing or verbally.
You likely can't join if
- ASPECTS score < 6
- Inclusion in other clinical trials.
- Occlusion in the vertebral, basilar, A2, P2, and M3-4 arteries.
- History of intracerebral hemorrhage
- Pregnant or lactating patient
- Patient with congestive heart failure or unstable or recent coronary artery disease (<3 months)
See the full eligibility criteria
- Patients with acute ischemic stroke and large intracranial vessel occlusion within 24 hours of symptom onset who have undergone mechanical thrombectomy.
- Successful recanalization, defined as a TICI score of 2b, 2c, or 3.
- Prior score on the modified Rankin Scale (mRS) of 0, 1, or 2.
- The patient or their legal representative provides informed consent in writing or verbally.
- ASPECTS score < 6
- Inclusion in other clinical trials.
- Occlusion in the vertebral, basilar, A2, P2, and M3-4 arteries.
- History of intracerebral hemorrhage
- Pregnant or lactating patient
- Patient with congestive heart failure or unstable or recent coronary artery disease (<3 months)
- Dissection of the aorta, cervical, or cerebral arteries, or unruptured aortic/cerebral aneurysm or known arteriovenous malformation
- Any visible hemorrhage on the initial CT scan
- History of ventricular arrhythmias
- Use of MAO inhibitors
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.