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Is adding Cilostazol to nimodipine improving neurological outcome of patients with Aneurysmal Subarachnoid Hemorrhage? A randomized, double blind, placebo-controlled trial. CASH
EU CTIS ID: 2024-516468-27-00
What this study is testing
Our main objective is to show that 100mg twice a day of cilostazol over 14 days improves the modified Rankin scale at 6-months in aneurysmal SAH treated with nimodipine, against placebo
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Adult patients admitted to an ICU with SAH related to a ruptured cerebral aneurysm occurring within the last 96 hours.
- Aneurysm successfully secured by surgical clipping or endovascular coiling
- Consent of the patient or, if not possible, from a proxy (emergency clause).
- Registration in a national health care system
You likely can't join if
- Precritical modified Rankin Scale (mRS) > 2
- Non-aneurysmal SAH
- Delayed > 96h admission after first symptoms of SAH
- Untreatable severe SAH with Hunt and Hess grade of V - Known allergy to cilostazol
- Pregnancy
- Pre-existing major hepatic, renal, pulmonary or cardiac disease
See the full eligibility criteria
- Adult patients admitted to an ICU with SAH related to a ruptured cerebral aneurysm occurring within the last 96 hours.
- Aneurysm successfully secured by surgical clipping or endovascular coiling
- Consent of the patient or, if not possible, from a proxy (emergency clause).
- Registration in a national health care system
- Precritical modified Rankin Scale (mRS) > 2
- Non-aneurysmal SAH
- Delayed > 96h admission after first symptoms of SAH
- Untreatable severe SAH with Hunt and Hess grade of V - Known allergy to cilostazol
- Pregnancy
- Pre-existing major hepatic, renal, pulmonary or cardiac disease
- Concomitant use of one other anti-platelet and/or anticoagulant agent
- Tutelage or guardianship
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.