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A randomized placebo-controlled double-blinded trial of the treatment of MRSA throat carriage with either standard decolonization therapy or standard decolonization therapy combined with oral clindamycin
EU CTIS ID: 2024-516377-69-01
What this study is testing
The main objective of this RCT is to investigate whether adding peroral clindamycin to the standard decolonization treatment with mupirocin nasal ointment and chlorhexidin body wash significantly improves the treatment success rate of MRSA throat carriers.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age ≥ 18 years
- MRSA carriage in the throat
- Has completed one standard topical decolonization treatment
You likely can't join if
- Pregnant or lactating woman
- Followed by specialist due to liver disease
- Severe overweight (BMI > 35) or weight < 50 kg
- Indwelling percutaneous permanent devices such as intravenous catheters or urinary tract catheters
- Daily contact with pigs or minks (decolonization therapy is generally not offered, according to The National Board of Health)
- Nursing home resident or health care worker (they have a more frequent control swab regime)
See the full eligibility criteria
- Age ≥ 18 years
- MRSA carriage in the throat
- Has completed one standard topical decolonization treatment
- Pregnant or lactating woman
- Followed by specialist due to liver disease
- Severe overweight (BMI > 35) or weight < 50 kg
- Indwelling percutaneous permanent devices such as intravenous catheters or urinary tract catheters
- Daily contact with pigs or minks (decolonization therapy is generally not offered, according to The National Board of Health)
- Nursing home resident or health care worker (they have a more frequent control swab regime)
- Not being capable of completing another treatment successfully
- MRSA positive household members younger than 2 years (MRSA positive children below 2 years of age and their household members are generally not offered decolonization treatment according to The National Board of Health)
- MRSA positive household members, where it is judged that further decolonization attempts are not indicated
- Sexually active women in the reproductive age that do not use approved contraceptives
- Cannot read or speak Danish or English
- Skin infection or other active infections
- Activity in skin diseases such as eczema or psoriasis
- MRSA isolate resistant to clindamycin (defined by inhibition zone size < 22 mm using disk diffusion methodology) or resistant to mupirocin
- Allergy to clindamycin, chlorhexidine or mupirocin
- Taking medications that interact with clindamycin according to the medicine information leaflet.
- MRSA active antibiotic treatment within 7 days before inclusion in the study or during study period
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.