Strategy To Optimize PeriproCeduraL AnticOagulation in Structural Transseptal Interventions (STOP CLOT Trial)

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• 1. Women who are pregnant or breastfeeding and those women of childbearing potential who do not agree to use at least two contraceptive measures (oral contraception, mechanical contraception, approved contraceptive implants, intrauterine device, tubal ligation). The criterion does not apply to women who have been postmenopausal for at least 2 years prior to study enrollment (defined as at least one year without menstrual periods) or underwent surgical sterilization procedure. All eligible women who are younger than 55 years must have negative pregnancy test within 24 hours prior to randomization. 2. Congenital or acquired bleeding disorders (i.e., diagnosed thrombophilia, bleeding diathesis, thrombocytopenia with platelet count <50 thousand/ml, INR elevation >1.5 due to the liver disease). 3. INR >1.5 within 24 hours prior to the procedure in patients chronically treated with vitamin K antagonists (applies to the last INR value prior to randomization). 4. Last dose of new oral anticoagulant <48 hours prior to the procedure (assessed at randomization). 5. Last dose of low molecular weight heparin <12 hours prior to the procedure (assessed at randomization). 6. Contraindications to MR imaging (i.e., claustrophobia, ferromagnetic intraocular foreign bodies, ferromagnetic metallic prostheses). 7. Implanted cardiac devices for electrotherapy if: - device has epicardial leads. - left disconnected leads or non-functional or damaged devices device implanted within abdominal wall. - the patient is pacemaker dependent (lack of escape rhythm >30/min). - the device was implanted or exchanged within 6 weeks prior to the MR. examination - device malfunction identified during the control performed prior to the MR examination, that in the opinion of electrophysiologist team may impact the safety of MR imaging. - low voltage of the device battery: the battery on the examination day should have at least 20% of the voltage value between the nominal value and elective replacement indicator (ERI) value, or the expected battery life calculated by the device should equal or exceed one year.