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Epinephrine versus Isoprenaline During Out-of-Hospital Cardiac Arrest with Non-Shockable Rhytm (EPISO)
EU CTIS ID: 2024-516074-29-00
What this study is testing
To determine whether the use of isoprenaline increases the chance of sustained return of spontaneous circulation during out-of-hospital cardiac arrest with non-shockable rhythm compared with epinephrine.
- Therapeutic confirmatory (Phase III)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Men and women with bystander and/or emergency medical service personnel witnessed out-of-hospital cardiac arrest.
- Age ≥18 years.
- Initial rhythm non-shockable rhythm (PEA or asystole).
- Advanced life support initiated or continued by EMS personnel.
You likely can't join if
- Cardiac arrest caused by or suspected to be caused by blunt trauma, penetrating trauma, or burn injury.
- Cardiac arrest caused by or suspected to be caused by drowning, hanging, strangulation, and foreign body airway obstruction.
- IV epinephrine already administered prior to EMS arrival.
- Prior enrollment in the trial.
- Patient with cardiac arrest at nursing homes.
- Known or apparent pregnancy.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.