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Serotonin and decision-making
EU CTIS ID: 2024-516055-41-00
What this study is testing
The role of serotonin in learning and decision-making: a behavioural study
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Healthy volunteers between 18-40 years of age
- For people able to bear children: negative pregnancy test taken during the intake ses-sion.
You likely can't join if
- (Known) hypersensitivity to escitalopram
- Prior to the testing sessions, use of alcohol within the last 24 hours before each measurement.
- Lifetime history of attempted suicide or current suicidal ideation.
- Habitual smoking, i.e., more than a pack of cigarettes per week and/or a self-reported inability or unease to cease smoking for 24 hours to testing.
- Abnormal hearing or (uncorrected) vision.
- Irregular sleep/wake rhythm (e.g., regular nightshifts or cross-time zone travel).
See the full eligibility criteria
- Healthy volunteers between 18-40 years of age
- For people able to bear children: negative pregnancy test taken during the intake ses-sion.
- (Known) hypersensitivity to escitalopram
- Prior to the testing sessions, use of alcohol within the last 24 hours before each measurement.
- Lifetime history of attempted suicide or current suicidal ideation.
- Habitual smoking, i.e., more than a pack of cigarettes per week and/or a self-reported inability or unease to cease smoking for 24 hours to testing.
- Abnormal hearing or (uncorrected) vision.
- Irregular sleep/wake rhythm (e.g., regular nightshifts or cross-time zone travel).
- Inability to complete the behavioural training successfully.
- Lifetime diagnosis of major depression, bipolar disorder, schizophrenia spectrum disorder, anorexia nervosa, personality disorder, and post-traumatic stress disorder
- History of pharmacological treatment of a psychiatric disorder (including MAO inhibitors, antidepressants, antipsychotic drugs)
- Lifetime diagnosis of relevant neurological disorder
- Current or history of severe substance use disorder (opiate, LSD, (meth)amphetamine, cocaine, solvents, XTC, MDMA, 3-MMC, GHB, heroin, nitrous oxide, or barbiturate), or alcohol use disorder.
- (History of) epilepsy in adulthood (i.e., no insult after 18 years of age, no current medication for epilepsy and no insult in the last five years)
- Average use of more than 3 alcohol beverages daily
- History of regular fainting (e.g., vasovagal reflex syncope).
- (History of) clinically significant/relevant hepatic, cardiac, obstructive respiratory, renal, gastrointestinal, cerebrovascular, cardiovascular, metabolic, endocrine, pancreatic, ocular or pulmonary disease/disorders
- • Use of any medication (prescribed/over the counter, including antibiotics and antihistamines but excluding paracetamol and contraceptive medication), and/or use of recreational drugs, or herbal remedies containing St John’s worth, during the study or within two weeks prior to the first behavioural session.
- Average use of psychotropic medication/recreational drugs once a week or more
- Unwillingness to refrain from drinking alcohol/only moderately consume alcohol for the duration of drug administration
- Possible pregnancy or breastfeeding
- No appropriate contraception (for people who can bear children)
- First degree family member with schizophrenia, bipolar disorder, or (known) suicide attempt.
- Periods of more than 3 months where cannabis was used weekly or more in the last 6 months
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.