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ASIC Channels and Migraine Disease - Proof-of-Concept Study on the Efficacy of Amiloride in Migraine Aura Prophylaxis
EU CTIS ID: 2024-516044-25-00
What this study is testing
To evaluate the efficacy of amiloride (non-specific ASIC-1 channel blocker) in the prophylaxis of migraine aura.
- Phase II and Phase III (Integrated)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Subjects aged 18 to 80
- Male or female
- Diagnosis of migraine with aura code 1.2.1 according to ICHD-3 including codes 1.2.1.1 and 1.2.1.2
- At least 1 attack with aura per month in the 3 months prior to inclusion
- Absence of prophylactic background antimigraine treatment for at least 1 month prior to inclusion
- For women of childbearing age, use of a reliable contraceptive method at least at least 3 months before and 1 month after the study
You likely can't join if
- Existence of contraindications to the use of amiloride
- Cardiovascular and renal history, for subjects over 75 years of age
- Athletes likely to be tested in competition and/or training
- Patients who, from the investigator's point of view, would not be compliant with the study procedure
- Pregnant or breast-feeding patients
- Patients under guardianship, curatorship or protected by law
See the full eligibility criteria
- Subjects aged 18 to 80
- Male or female
- Diagnosis of migraine with aura code 1.2.1 according to ICHD-3 including codes 1.2.1.1 and 1.2.1.2
- At least 1 attack with aura per month in the 3 months prior to inclusion
- Absence of prophylactic background antimigraine treatment for at least 1 month prior to inclusion
- For women of childbearing age, use of a reliable contraceptive method at least at least 3 months before and 1 month after the study
- Signature of written informed consent
- Patient affiliated to social security
- Existence of contraindications to the use of amiloride
- Cardiovascular and renal history, for subjects over 75 years of age
- Athletes likely to be tested in competition and/or training
- Patients who, from the investigator's point of view, would not be compliant with the study procedure
- Pregnant or breast-feeding patients
- Patients under guardianship, curatorship or protected by law
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.