Authorised Phase III and phase IV (Integrated) Out-of-hospital cardiac arrest

Ketamine sedation as neuroprotective agent following out-of-hospital cardiac arrest

EU CTIS ID: 2024-515987-29-00

What this study is testing

To determine the neuroprotective efficacy of ketamine compared with propofol administered as part of sedation for intubation after initial resuscitation from OHCA.

  • Phase III and phase IV (Integrated)

A plain-language read of the study's public EU CTIS listing. The study team confirms the details.

Who can take part

You may be able to join if

  • 1. Age ≥18 years (presumed if not known) 2. OHCA of presumed cardiac cause. * 3. Primary shockable rhythm (ventricular fibrillation or pulseless ventricular tachycardia) ** 4. Decision to perform prehospital intubation after resuscitation (as decided by treating physician) or intubated during CPR with additional need for sedation. 5. Administration of study medicine injection before hospital arrival is considered feasible. 6. ROSC with MAP ≥40 mmHg *i.e. admission to Rigshospitalet or Odense University Hospital: national guidelines state that all OHCA patients with presumed cardiac arrest must be referred to the two main hospitals in the respective regions — Rigshospitalet for all OHCA cases in Region Zealand and the Capital Region, and Odense University Hospital for all OHCA cases in Region South. **If a defibrillator shock by an automated external defibrillator is delivered or advised before arrival of the EMS, it is considered a “primary shockable rhythm.”

You likely can't join if

  • 1. Advanced life support TOR exclusion criteria fulfilled 2. Refractory cardiac arrest transferred for extracorporeal membrane oxygenation 3. Woman of childbearing capacity (female aged 18-40, decided by the treating physician if no information is available) 4. Known therapy limitation (known decision made of no resuscitation or intensive therapy) 5. Known allergy to ketamine or propofol 6. Systolic blood pressure >190 mmHg 7. Known chronic disease making 180-day survival unlikely 8. Known pre-arrest mRS score of ≤5 9. Nursing home resident 10. Temperature upon admission <30° C

The study team makes the final eligibility decision.

Questions & answers

Do participants get paid in this trial?

This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.

Is it free to join, and do I need insurance?

Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.

How long does this study last?

The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.

Who can join this trial?

This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.

Explore other conditions

BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.