Exploration of the pathophysiology of cluster headache (AVF) in PET-MRI using [18F]F13640

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• Patients with present or past dependence on alcohol or any other addictive substance according to DSM-IV-TR criteria, with the exception of nicotine, caffeine and cannabis
• • Patients already participating in another biomedical research project or having participated for less than a year in a study using ionizing radiation
• Patients with a contraindication to MRI examinations: people suffering from claustrophobia and/or people using a pacemaker or an insulin pump, people wearing a metal prosthesis or an intracerebral clip as well as claustrophobic subjects, neurosensory stimulator or defibrillator implantable, cochlear implants, ferromagnetic ocular or cerebral foreign bodies close to nervous structures, agitation of the subject (uncooperative or agitated subjects), neurosurgical ventriculoperitoneal diversion valves, dental appliance;
• •Patients with a contraindication to [18F]F13640 PET examinations: hypersensitivity to the active substance or to one of the excipients (sodium chloride);
• Patients with a contraindication to sumatriptan: hypersensitivity to sumatriptan or to one of the excipients, history of myocardial infarction or ischemic heart disease, coronary vasospasm (Prinzmetal's angina), peripheral vascular disease, cardiac disease ishcemic, history of stroke or TIA, severe hepatic impairment, moderate or severe hypertension and in patients with mild uncontrolled hypertension, ergotamine or ergotamine derivatives (including methysergide), another triptan/receptor agonist 5-hydroxytriptamine1 (5-HT1), combination of sumatriptan with monoamine oxidase inhibitors or within two weeks after stopping treatment with monoamine oxidase inhibitors;
• Patients presenting an inability to understand or carry out the study (language barrier, obvious lack of motivation, etc.) judged by the investigator;