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Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) versus Conventional Treatment in Acute Myocarditis: INFLAMA study
EU CTIS ID: 2024-513803-15-00
What this study is testing
The main objective is to assess the utility of ibuprofen therapy for 3 weeks versus conventional treatment with analgesics (paracetamol) in acute myocarditis with preserved left ventricular ejection fraction, in terms of reducing late gadolinium enhancement on cardiac magnetic resonance at 6-month follow-up.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Aged 18 years or older.
- Patients hospitalized for confirmed acute myocarditis and left ventricular ejection fraction ventricular ≥50%.
- Absence of acute heart failure.
- Exclusion of ischemic heart disease.
- Diagnostic criteria for myocarditis by cardiac magnetic resonance imaging.
- Ability to provide informed consent.
You likely can't join if
- Kidney disease stage 3b, 4 and 5 or severe liver failure.
- Uncontrolled hypertension.
- Diagnosis criteria for acute pericarditis.
- Moderate or severe pericardial effusion.
- Hypersensitivity to Non-steroidal anti-inflammatory drugs or previous use in the last seven days.
- Contraindication for cardiac magnetic resonance.
See the full eligibility criteria
- Aged 18 years or older.
- Patients hospitalized for confirmed acute myocarditis and left ventricular ejection fraction ventricular ≥50%.
- Absence of acute heart failure.
- Exclusion of ischemic heart disease.
- Diagnostic criteria for myocarditis by cardiac magnetic resonance imaging.
- Ability to provide informed consent.
- Kidney disease stage 3b, 4 and 5 or severe liver failure.
- Uncontrolled hypertension.
- Diagnosis criteria for acute pericarditis.
- Moderate or severe pericardial effusion.
- Hypersensitivity to Non-steroidal anti-inflammatory drugs or previous use in the last seven days.
- Contraindication for cardiac magnetic resonance.
- Pregnancy, breastfeeding, or women of childbearing age unwilling to use appropriate contraception throughout the duration of the treatment of the study
- Known autoimmune disease that, in the investigator's opinion, could be the cause of myocarditis and requires immunosuppressive treatment.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.