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Chronic kidney disease – imaging the metabolic derangements with ultra-sensitive MRI
EU CTIS ID: 2024-512491-35-00
What this study is testing
In this study, we aim to assess the metabolic signature of CKD and PDK using multi-parametric MRI. The study will include healthy volunteers (N=8), CKD patients (N=12), PKD patients (N=10). PDK patients: a. The metabolic shift towards glycolysis compared with healthy kidneys can be detected using MRI with hyperpolarized pyruvate. CKD patients a. Multi-parametric MRI combined with hyperpolarized pyruvate MRI can detect the metabolic alterations, including upregulated lactate and alanine production, associated with CKD. b. These alterations correlate with measures of fibrosis and inflammation from biopsies
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Aged 18 – 85 years (all participants)
- Pre-menopausal women must be confirmed non-pregnant by an onsite test. (All female participants)
- Autosomal dominant polycystic kidney disease. (PKD group)
- CKD for any reason except PKD. (CKD group)
- Recent biopsy (within 6 months of MRI). (CKD group)
- eGFR > 60 (PKD patients)
You likely can't join if
- Contraindications for MRI: - Significant cardiac disease such as severe left ventricular outflow obstruction - Significant obstructive lung disease or severe asthma - Pacemaker, neurostimulator or cholera implant - Metal foreign bodies such as fragments and irremovable piercings - Unsafe medical implants (safety of heart valves, hips and the like must be confirmed) - Claustrophobia - Largest circumference including arms > 160 cm
- Competing renal or systemic disease (except unspecific renal MRI findings, hypertension, atherosclerosis, well-regulated diabetes and hyperlipidemia/cholesterolemia which are allowed)
- Renovascular disease
- Allergy to pyruvate
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.