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Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE)
EU CTIS ID: 2024-512407-39-00
What this study is testing
To investigate whether beta-blocker treatment to patients with COPD and no co-existing cardiovascular disease protects against exacerbations of COPD, cardiovascular events and death
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- A diagnosis of COPD confirmed by spirometry showing post bronchodilator value of Forced Expiratory Volume in one second (FEV1)//Forced Vital Capacity (FVC) <70 according to the Global Initiative on Obstructive Pulmonary Disease (GOLD), and with a history of tobacco smoking or occupational/environmental exposure for smoke gas or dust
- ≥40 years of age
- Sinus rhythm ≥50/min and <120 at inclusion
- Written informed consent
You likely can't join if
- Known hypersensitivity to metoprolol or related derivatives
- Systolic blood pressure <90 mmHg
- Severe bronchial asthma
- Current beta-blocker treatment
- Inability to provide informed consent
- Age below 40 years
See the full eligibility criteria
- A diagnosis of COPD confirmed by spirometry showing post bronchodilator value of Forced Expiratory Volume in one second (FEV1)//Forced Vital Capacity (FVC) <70 according to the Global Initiative on Obstructive Pulmonary Disease (GOLD), and with a history of tobacco smoking or occupational/environmental exposure for smoke gas or dust
- ≥40 years of age
- Sinus rhythm ≥50/min and <120 at inclusion
- Written informed consent
- Known hypersensitivity to metoprolol or related derivatives
- Systolic blood pressure <90 mmHg
- Severe bronchial asthma
- Current beta-blocker treatment
- Inability to provide informed consent
- Age below 40 years
- Acute on-going exacerbation of COPD
- Previous randomization in the BRONCHIOLE trial
- Ongoing pregnancy (excluded by pregnancy test in fertile women)
- AV block II or III unless treated with a pacemaker
- Sinus bradycardia (resting heart rate <50/min)
- Sick sinus syndrome unless treated with a pacemaker
- Atrial fibrillation/flutter (AF)
- Clinical signs of or a previous diagnosis of left-sided heart failure (HF), angina pectoris (AP), myocardial infarction (MI), cerebrovascular disease or critical peripheral ischemia
- Systolic blood pressure <90 mmHg
- Any tachyarrythmias other than sinus rhythm
- Sinustachycardia >120 / min
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.