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Investigating cardiometabolic risk factors and changes in chronobiology patterns in patients with autonomous adrenal cortisol secretion
EU CTIS ID: 2024-512100-19-00
What this study is testing
Cardiometabolic phenotyping of patients suffering from autonomous cortisol secretion and identifying a disease specific chronobiology profile in patients with altered hypothalamus-pituitary-adrenal (HPA) axis signaling
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Group autonomous cortisol secretion: Inclusion criteria for the ACS group: • Age > 18 years • History of an adrenal adenoma • morning cortisol > 1.8 ug/dl following 1 mg dexamethasone suppression test • No classical clinical features associated with the presence of Cushing’s syndrome, Control group: • Age > 18 years • History of an adrenal adenoma • morning cortisol of ≤ 1.8 ug/dl following 1 mg dexamethasone suppression testing
You likely can't join if
- • HbA1c > 8 % and/or treatment with insulin therapy 14 Proposal_AdrenalClock_V4 18.03.2023 • uncontrolled hypertension (RR > 170/110 mmHg; treatment with no more than 4 antihypertensive drugs) • previous treatment with glucocorticoids within the last 3 months • concomitant treatment with drugs affecting HPA signaling or CYP3A4 metabolism • adrenal tumor with radiological criteria suspicious for malignancy • chronic kidney disease (eGFR < 45 ml/min) • liver disease (ASAT / ALAT > 3 x ULN) • pregnancy or breast feeding • general MR contraindications (claustrophobia, metal devices or other magnetic material in the body which will be hazardous for MR investigation
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.