Ended Therapeutic use (Phase IV) ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI)

ARMYDA TICA-MI study

EU CTIS ID: 2024-511944-18-01

What this study is testing

The aim of this study will be to determine whether early administration of oral ticagrelor loading dose, at the initiation of cangrelor infusion, is superior to its late administration (30 minutes before the end of cangrelor infusion) in reducing the incidence of high platelet reactivity (HPR) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI).

  • Therapeutic use (Phase IV)

A plain-language read of the study's public EU CTIS listing. The study team confirms the details.

Who can take part

You may be able to join if

  • Diagnosis of ST-elevation myocardial infarction (STEMI) scheduled for primary percutaneous coronary intervention (pPCI); age 18 years or older; informed consent provided; - Clinical indication to administer cangrelor and ticagrelor.

You likely can't join if

  • - Any conditions that, in the opinion of the investigator, contraindicates antiplatelet therapy or would have an unacceptable risk of bleeding. - Clinically significant ongoing bleeding. - Injuries or conditions that significantly increase the risk of major bleeding (these may include recent or ongoing gastric ulceration, presence of cancer with high risk of bleeding, recent brain or spinal trauma, recent brain, spinal or ophthalmic surgery, recent intracranial hemorrhage, known or suspected esophageal varices, arteriovenous malformations, vascular aneurysms or major intraspinal or intracerebral vascular dysfunctions). - Hypersensitivity to the active substance or to any of the excipients. - Known end stage renal disease on hemodialysis. - Known severe hepatic dysfunction. - Acute or severe bronchial asthma or upper airway obstruction. - Current treatment with drugs interfering with CYP3A4 metabolism (to avoid interaction with ticagrelor): Ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir, and telithromizycin. - Treatment with a P2Y12 receptor antagonist (ticlopidine, clopidogrel, prasugrel, ticagrelor) within 7 days. - Treatment with oral anticoagulant (Vitamin K antagonists, dabigatran, rivaroxaban, apixaban, edoxoban) within 7 days. - Known platelet count <100x106/mL. - Known hemoglobin <10 g/dL. - Known hematocrit < 28% - Pregnancy (to be ascertained with pregnancy tests in women of childbearing potential) and breastfeeding. - Inability to provide informed consent.

The study team makes the final eligibility decision.

Questions & answers

Do participants get paid in this trial?

This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.

Is it free to join, and do I need insurance?

Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.

How long does this study last?

The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.

Who can join this trial?

This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.

Explore other conditions

BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.