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Treatment with acetylcholine esterase inhibitors in anorexia nervosa : a multicenter double-blind randomised controlled trial versus placebo
EU CTIS ID: 2024-511681-37-00
What this study is testing
Evaluate the effect, compared with placebo, of oral administration of donepezil (an acetylcholinesterase inhibitor) on improvement in the symptomatology of anorexia nervosa.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- female
- Presence of 3 DSM V criteria for anorexia nervosa
- Restrictive subtype of anorexia nervosa
- Body Mass Index between 14 and 18.5 kg/m2
- Aged between 18 and 65
- Resting heart rate greater than or equal to 40 bpm
You likely can't join if
- Past diagnosis of anorexia nervosa in the form of hyperphagia/purgation
- Pregnant or breast-feeding women
- Past diagnosis of bulimia nervosa
- Past diagnosis of binge eating disorder
- Comorbid diagnosis of psychotic disorder and/or bipolar disorder
- Renal impairment (glomerular filtration rate less than 60 mL/min according to the MDRD formula)
See the full eligibility criteria
- female
- Presence of 3 DSM V criteria for anorexia nervosa
- Restrictive subtype of anorexia nervosa
- Body Mass Index between 14 and 18.5 kg/m2
- Aged between 18 and 65
- Resting heart rate greater than or equal to 40 bpm
- Past diagnosis of anorexia nervosa in the form of hyperphagia/purgation
- Pregnant or breast-feeding women
- Past diagnosis of bulimia nervosa
- Past diagnosis of binge eating disorder
- Comorbid diagnosis of psychotic disorder and/or bipolar disorder
- Renal impairment (glomerular filtration rate less than 60 mL/min according to the MDRD formula)
- Liver failure or transaminase elevation greater than 5N
- Electrocardiogram of conduction disorder
- Taking a psychotropic drug now or in the three weeks prior to inclusion (including antidepressants, to avoid interaction/potentiation in this population)
- Taking a treatment involving the following cytochromes : P450, P3A4, P2D6
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.