Authorised Phase III and phase IV (Integrated) Pancreatoduodenectomy with a high risk for contaminated bile

(SPARROW) Standard versus Pre-emptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes after Whipple’s procedure (SPARROW): a multicenter, randomized controlled trial

Q: Do participants get paid in this trial?

This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.

Q: Is it free to join, and do I need insurance?

Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.

Q: How long does this study last?

The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.

Q: Who can join this trial?

This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.

EU CTIS ID: 2024-510766-16-00

What this study is testing

The primary endpoint is the occurrence of a clinically relevant OSI and must meet the following criteria (based on the CDCdefinition): A deep surgical site infection involving any part of the abdomen (e.g. organs and/or spaces) other than the surgical incision within90 days after surgery. AND Requires radiological, endoscopic or surgical intervention OR therapeutic antibiotics required for an episode of sepsis,defined as two or more SIRS criteria. AND Organisms isolated from an aseptically obtained culture.

Phase III and phase IV (Integrated)

A plain-language read of the study's public EU CTIS listing. The study team confirms the details.

Who can take part

You may be able to join if

Patients undergoing elective pancreatoduodenectomy with a high risk for contaminated bile defined as patients with preoperative biliary drainage or an ampullary malignancy.
Age >18 years

You likely can't join if

Pregnancy
Contraindication for the study antibiotics (e.g. allergy or intolerance)
Indication for endocarditis prophylaxis
Preoperative planned therapeutic antibiotic treatment after surgery (i.e. for cholangitis or liver abscesses)
A reduced renal function, defined as a eGFR of <60 ml/min/1.73m2 and measured on a the closest timepoint prior to pancreatoduodenectomy

The study team makes the final eligibility decision.

Questions & answers

Do participants get paid in this trial?

This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.

Is it free to join, and do I need insurance?

Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.

How long does this study last?

The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.

Who can join this trial?

This study is enrolling all sexes, 65+ years, 18-64 years. The study team makes the final eligibility decision.

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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.