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General anesthesia versus sedation with high-flow nasal cannula for the endovascular treatment of acute ischemic stroke
EU CTIS ID: 2024-510752-12-00
What this study is testing
The primary objective of the study is to assess the time from hospital arrival to revascularization in patients with acute ischemic stroke treated with mechanical thrombectomy, depending on whether the procedure was performed under sedation with HFNC or under general anesthesia.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age greater than or equal to 18 years.
- NIHSS ≥ 6 and ≤ 25.
- Anterior circulation stroke with isolated or combined occlusion of: - Intracranial Internal Carotid Artery. - Middle Cerebral Artery in its M1 or M2 segments.
- Time of evolution from clinical onset to radiology ward admission < 6 hours, or < 24 hours since last seen asymptomatic if salvageable tissue is demonstrated on neuroimaging tests.
- Informed consent signed by the patient if capable, or by a family member/legal representative if the patient is not capable.
You likely can't join if
- Coma on admission (Glasgow Coma Scale < 8).
- Baseline severe dependency status (mRS>3).
- Severe/significant agitation on admission.
- Objective loss of airway protection reflexes or vomiting on admission.
- Failure to comply with fasting (6 hours of solids and 2 hours of clear liquids).
- Known or suspected difficult airway on examination.
See the full eligibility criteria
- Age greater than or equal to 18 years.
- NIHSS ≥ 6 and ≤ 25.
- Anterior circulation stroke with isolated or combined occlusion of: - Intracranial Internal Carotid Artery. - Middle Cerebral Artery in its M1 or M2 segments.
- Time of evolution from clinical onset to radiology ward admission < 6 hours, or < 24 hours since last seen asymptomatic if salvageable tissue is demonstrated on neuroimaging tests.
- Informed consent signed by the patient if capable, or by a family member/legal representative if the patient is not capable.
- Coma on admission (Glasgow Coma Scale < 8).
- Baseline severe dependency status (mRS>3).
- Severe/significant agitation on admission.
- Objective loss of airway protection reflexes or vomiting on admission.
- Failure to comply with fasting (6 hours of solids and 2 hours of clear liquids).
- Known or suspected difficult airway on examination.
- Allergy or intolerance to any of the medications used for sedation or general anesthesia.
- Recent maxillofacial trauma/surgery.
- Acute cerebral hemorrhage or clear hemorrhagic transformation in the same vascular territory.
- Thrombopenia <50,000 or severe coagulation disturbances.
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.