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Longitudinal multicenter head-to-head harmonization of tau PET tracers (HEAD Study)
EU CTIS ID: 2023-510508-31-01
What this study is testing
Compare cross-sectional and longitudinal measures of tau obtained with these three second-generation PET tau tracers ([18F]RO948, [18F]PI2620, and [18F]MK-6240) directly in the same volunteers to elucidate the advantages and limitations of their use in research cohorts, clinical trials, and clinical practice.
- Therapeutic exploratory (Phase II)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- For Healthy Cognitive Controls: Age: > 18 years (minimum N=5 young individuals aged between 18 and 28) Clinical Criterion: CDR = 0
- Mild Cognitive Impairment (MCI): Age: 50-90 years (inclusive) Clinical Criteria: NIA-AA 2018, MMSE (22-28)
- Alzheimer's Disease (AD): Age: 50-90 years (inclusive) Clinical Criteria: NIA-AA 2018, MMSE (11-24)
- Frontotemporal Dementia: Age: 50-90 years (inclusive) Clinical Criteria: Rascovsky et al., 2011
- Primary Progressive Aphasia: Age: 50-90 years (inclusive) Clinical Criteria: Gorno-Tempini et al., 2011
- Progressive Supranuclear Palsy: Age: 50-90 years (inclusive) Clinical Criteria: Hoglinger et al., 2017
You likely can't join if
- Patient with out inclusion criteria
See the full eligibility criteria
- For Healthy Cognitive Controls: Age: > 18 years (minimum N=5 young individuals aged between 18 and 28) Clinical Criterion: CDR = 0
- Mild Cognitive Impairment (MCI): Age: 50-90 years (inclusive) Clinical Criteria: NIA-AA 2018, MMSE (22-28)
- Alzheimer's Disease (AD): Age: 50-90 years (inclusive) Clinical Criteria: NIA-AA 2018, MMSE (11-24)
- Frontotemporal Dementia: Age: 50-90 years (inclusive) Clinical Criteria: Rascovsky et al., 2011
- Primary Progressive Aphasia: Age: 50-90 years (inclusive) Clinical Criteria: Gorno-Tempini et al., 2011
- Progressive Supranuclear Palsy: Age: 50-90 years (inclusive) Clinical Criteria: Hoglinger et al., 2017
- Corticobasal Degeneration: Age: 50-90 years (inclusive) Clinical Criteria: Armstrong et al., 2013
- Dementia with Lewy Bodies: Age: 50-90 years (inclusive) Clinical Criteria: McKeith et al., 2017
- Down's Syndrome (SD): Age: > 18 years
- Patient with out inclusion criteria
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.