Fecal Microbiota Transplantation to RESCUE patients with unresectable Hcc progressors to first line therapy with AtezolizUmaB and Bevacizumab (RESCUE-HUB)

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• History of leptomeningeal disease or brain metastases. Active or history of autoimmune disease or immune deficiency, including, but not limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjögren syndrome, Guillain-Barré syndrome, or multiple sclerosis, with some expceptions (see full protocol for details). ● History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan. Active tubercolosis. Significant cardiovascular disease (...) within 3 months prior to initiation of study treatment, unstable arrhythmia, or unstable angina History of congenital long QT syndrome or corrected QT interval >500 ms (...) at screening Active malignancy in advanced stage other than HCC within 1 year prior to screening (....) Prior severe adverse reaction to either Atezolizumab or Bevacizumab which either was not manageable with low dose steroid therapy or required a treatment interruption. History of uncorrectable electrolyte disorder affecting serum levels of potassium, calcium, or magnesium Major surgical procedure, other than for diagnosis, within 4 weeks prior to initiation of study treatment, or anticipation of need for a major surgical procedure during the study Severe infection within 4 weeks prior to initiation of study treatment, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia or any active infection that could impact patient safety Treatment with therapeutic oral or IV antibiotics within 2 weeks prior to initiation of study treatment Patients receiving prophylactic antibiotics (e.g., to prevent a urinary tract infection or chronic obstructive pulmonary disease (COPD) exacerbation) are eligible for the study. Antibiotics administered within 30 days prior to initiation of study treatment have to be recorded in eCRF. Prior allogeneic stem cell or solid organ transplantation Any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates the use of an investigational drug, may affect the interpretation of the results, or may render the patient at high risk from treatment complications Treatment with a live, attenuated vaccine within 4 weeks prior to initiation of study treatment, or anticipation of need for such a vaccine during atezolizumab treatment or within 5 months after the last dose of atezolizumab History of severe allergic anaphylactic reactions to chimeric or humanized antibodies or fusion proteins Known hypersensitivity to Chinese hamster ovary cell products or to any component of the atezolizumab or bevacizumab formulation Pregnancy or breastfeeding, or intention of becoming pregnant during study treatment or within at least 5 months after the last dose of atezolizumab and 6 months after the last dose of bevacizumab Women of childbearing potential must have a negative serum pregnancy test result within 14 days prior to initiation of study treatment Known fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC Untreated or incompletely treated esophageal and/or gastric varices with bleeding or high-risk for bleeding (see full protocol for details)