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The effect of different antibiotic protocols for dental implant surgery on peri-implant tissue health and on oral microbiome and resistome
EU CTIS ID: 2023-510391-31-00
What this study is testing
The aim of the study is to evaluate if the short-span antibiotic therapy with amoxicillin per os is not inferior compared to the long-span antibiotic prescription in favouring peri-implant tissue healing (i.e. less peri-implant bone loss), while at the same time reducing the risk of developing antimicrobial resistance.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Patients requiring one single implant or partial implant-supported rehabilitation in an edentulous area of the posterior mandible or maxilla
You likely can't join if
- - Patients unable to commit to follow-up - General contraindications to implant surgery - Immuno-suppressed/immune-compromised patients - Patients irradiated in the head and/or neck - Uncontrolled diabetes - Pregnancy, childbearing potential, breastfeeding - Smoking habit - Untreated periodontal disease (Caton et al, J Clin Periodontol 2018) - Poor oral hygiene and motivation (plaque index > 20%) - Addiction to alcohol or drugs - Psychiatric problems and/or unrealistic expectations - Patients with an acute infection (abscess) or suppuration in the site intended for implant placement - Patients treated or under treatment with intravenous amino-bisphosphonates - Patients referred only for implant placement if the follow-up cannot be done at the treatment center - Patients participating in other studies, if the present protocol could not be fully adhered to - Patients with allergy/hypersensitivity to penicillin or drug excipients - Patients recently treated with antibiotics for other indications
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.