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Feasibility of short-term temporary discontinuation of serotonin reuptake inhibitors in patients planned for hip or knee arthroplasty
EU CTIS ID: 2023-509988-24-00
What this study is testing
To investigate the feasibility of short-term temporary discontinuation of SSRIs and SNRIs in a selected group of hip and knee arthroplasty patients with a focus on discontinuation syndrome and relapse of depression and anxiety
- Phase III and phase IV (Integrated)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- 18 years of age or older at the time of inclusion
- Planed for primary unilateral THA/TKA/UKA
- Oral treatment with SSRI/SNRI*-tablet(s)/capsule(s) in any dose (*ATC codes: N06AB04, N06AB06, N06AB10, N06AB05, N06AX21)
- Understand written and spoken Danish language
- Signed written informed consent form
You likely can't join if
- Earlier suicide attempt(s)
- Suicidal ideation
- Treatment with other psychopharmacological drugs than SSRIs/SNRIs except benzodiazepines** and 50 mg quetiapine (** ATC codes: N05BA*, N05CD* and N05CF)
- Depression or anxiety symptoms at the time of inclusion (MDI > 19 or SCL-92(anxiety) > Q3(sex))
- 2 or more depressive episodes the last 5 years
- Previous unsuccessful tapering of SSRIs/SNRIs
See the full eligibility criteria
- 18 years of age or older at the time of inclusion
- Planed for primary unilateral THA/TKA/UKA
- Oral treatment with SSRI/SNRI*-tablet(s)/capsule(s) in any dose (*ATC codes: N06AB04, N06AB06, N06AB10, N06AB05, N06AX21)
- Understand written and spoken Danish language
- Signed written informed consent form
- Earlier suicide attempt(s)
- Suicidal ideation
- Treatment with other psychopharmacological drugs than SSRIs/SNRIs except benzodiazepines** and 50 mg quetiapine (** ATC codes: N05BA*, N05CD* and N05CF)
- Depression or anxiety symptoms at the time of inclusion (MDI > 19 or SCL-92(anxiety) > Q3(sex))
- 2 or more depressive episodes the last 5 years
- Previous unsuccessful tapering of SSRIs/SNRIs
- Drug dependency
- Pregnancy
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.