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Duration of peripheral nerve blocks in opioid tolerant individuals
EU CTIS ID: 2023-509351-13-00
What this study is testing
To evaluate the onset time and duration of a radial nerve block in opioid tolerant individuals compared to opioid naive individuals.
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Age > 18 years old
- ASA 1-3
- Legally competent and able to give informed consent
- Chronic pain, defined as persisting pain for more than three months (opioid group)
- The daily use of 60 mg or more of morphine equivalent for more than a month (opioid group)
You likely can't join if
- Volunteers who cannot cooperate with the study
- Pathology or previous major surgery to the upper limb
- Active signs of infection in the cutaneous area of injection
- Pregnancy at the time of the trial
- Volunteers diagnosed with partial or complete 2nd or 3rd degree atrioventricular heart block without a pacemaker
- Age > 84 years
See the full eligibility criteria
- Age > 18 years old
- ASA 1-3
- Legally competent and able to give informed consent
- Chronic pain, defined as persisting pain for more than three months (opioid group)
- The daily use of 60 mg or more of morphine equivalent for more than a month (opioid group)
- Volunteers who cannot cooperate with the study
- Pathology or previous major surgery to the upper limb
- Active signs of infection in the cutaneous area of injection
- Pregnancy at the time of the trial
- Volunteers diagnosed with partial or complete 2nd or 3rd degree atrioventricular heart block without a pacemaker
- Age > 84 years
- Volunteers diagnosed with severe liver disease
- Volunteers diagnosed with severe kidney disease and reduced kidney function (eGFR below 30 mL/min)
- Volunteers in daily treatment with drugs that are structurally related to local analgesics or class IB antiarrhythmics, as the toxic effects are additive
- Volunteers in daily treatment with class III antiarrhythmics e.g., amiodarone.
- Volunteers who cannot understand or speak Danish
- Volunteers with allergy to the lidocaine or the preservatives used in the study
- Volunteers suffering from alcohol or drug abuse other than opioids
- Peripheral neuropathy at the upper limb non-dominant arm
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years. The study team makes the final eligibility decision.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.