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The SANT-study - A randomized controlled clinical trial of Streptococcus group A-negative acute tonsillitis in primary health care - a comparison of phenoxymethylpenicillin and no antibiotic treatment
EU CTIS ID: 2023-508542-18-00
What this study is testing
Determine if PcV compared to no antibiotic treatment (care as usual) reduces the duration of symptoms in patients with severe (Centor score 3-4), GAS-negative AT
- Therapeutic use (Phase IV)
A plain-language read of the study's public EU CTIS listing. The study team confirms the details.
Who can take part
You may be able to join if
- Adult and young adult persons ages 15 years and older with symptoms of sore throat and or pain on swallowing
- Centor score 3-4: absence of cough, anamnestic fever (temperature above 38.5°C), tender lymphadenitis, and tonsillar exudates (one or both tonsils)
- Duration of symptoms < 8 days
- A RADT for GAS taken
- Willing and able to give informed consent. Subjects under 18 years of age must in addition have the consent from both parents/caretakers
You likely can't join if
- Ongoing antibiotic treatment
- Known or suspected allergies to penicillin
- Strong suspicion of mononucleosis and positive point of care test
- Suspicion of PTA or indication for admittance
The study team makes the final eligibility decision.
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18-64 years, 65+ years, 0-17 years. The study team makes the final eligibility decision.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from EU CTIS; the study team decides eligibility.