A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma

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• 1. Any of the following treatment interventions within the specified time frame prior to C1D1: • Major surgery within 28 days and any preplanned major surgery during the study treatment period. • Any chemotherapy or targeted tumor therapy within 14 days or 5 half-lives (whichever is shorter). • Radiation within 21 days. • Autologous or allogeneic stem cell transplant within 3 months. • Current use of any other investigational drug therapy <28 days or 5 half-lives (whichever is shorter) • Inability to discontinue treatment with drugs, or to discontinue food and herbal supplements, that are strong or moderate CYP3A inhibitors and inducers, or P-gp inhibitors at least 14 days prior to start of study drug treatment. Mandatory anti-emetics that may be CYP3A inhibitors are an exception to this criterion 2. Prior therapy with ZN-c3 or any other WEE1 inhibitor, ATR inhibitor, or CHK1/2 inhibitor 3. Known hypersensitivity to ZN-c3 or any of the inactive ingredients in ZN-c3
• 4. A serious illness or medical condition(s) including, but not limited to, the following: • Brain metastases that require immediate treatment or are clinically or radiologically unstable • Leptomeningeal disease that requires or is anticipated to require immediate treatment • Myocardial impairment of any cause resulting in heart failure by New York Heart Association Criteria (Class III or IV) • Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the Investigator would make the subject inappropriate for entry into this study • Significant gastrointestinal abnormalities, considered to be clinically significant in the judgrior to C1D1, rement of the Investigator, or prior surgical procedures affecting absorption • Active, uncontrolled systemic infection. • Any evidence of bowel obstruction , recent hospitalization for bowel obstruction within 3 months prior to C1D1, or paracentesis/ thoracentesis within 3 weeks pcurrent paracentesis or thoracentesis within 6 weeks prior to C1D1 5, or paracentesis/thoracentesis anticipated during C1. Unresolved toxicity of Grade >1 attributed to any prior therapies
• 6. Pregnant or lactating females or females of childbearing potential who have a positive serum pregnancy test within 14 days prior to C1D1 7. History of another malignancy in the previous 2 years, unless cured by surgery alone and continuously disease free. 8. Individuals who are judged by the Investigator to be unsuitable as study subjects